GABRA6

Description		gamma-aminobutyric acid type A receptor subunit alpha6
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Dendrite Membrane Chloride Channel Complex Synapse Postsynaptic Membrane Postsynapse Cerebellar Golgi Cell To Granule Cell Synapse Postsynaptic Specialization Membrane GABA-A Receptor Complex
	Molecular Function	Transmembrane Signaling Receptor Activity GABA-A Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Activity Benzodiazepine Receptor Activity GABA-gated Chloride Ion Channel Activity Signaling Receptor Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Monoatomic Ion Transport Chloride Transport Signal Transduction Gamma-aminobutyric Acid Signaling Pathway Monoatomic Ion Transmembrane Transport Synaptic Transmission, GABAergic Regulation Of Postsynaptic Membrane Potential Chloride Transmembrane Transport Inhibitory Synapse Assembly
Pathways		GABA receptor activation GABA receptor activation
Drugs		Lorazepam Ethchlorvynol Enflurane Temazepam Butabarbital Butalbital Butalbital Phenytoin Etomidate Talbutal Talbutal Pentobarbital Pentobarbital Clobazam Meprobamate Meprobamate Eszopiclone Alprazolam Secobarbital Metharbital Metharbital Chlordiazepoxide Amoxapine Adinazolam Lamotrigine Thiopental Medroxyprogesterone acetate Clorazepic acid Midazolam Flurazepam Isoflurane Primidone Primidone Halazepam Propofol Diazepam Oxazepam Methylphenobarbital Triazolam Ethanol Methoxyflurane Memantine Clonazepam Methyprylon Halothane Desflurane Flumazenil Estazolam Sevoflurane Amobarbital Aprobarbital Butobarbital Heptabarbital Hexobarbital Glutethimide Barbital Camazepam Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione Delorazepam Flunitrazepam Ethyl loflazepate Cloxazolam Bromazepam Clotiazepam Ketazolam Prazepam Quazepam Cinolazepam Nitrazepam Prasterone Taurine Ganaxolone Brotizolam Stiripentol Etizolam Thiocolchicoside Brexanolone Apalutamide Remimazolam 1,2-Benzodiazepine Pinazepam Medazepam Loprazolam Doxefazepam Lormetazepam Nordazepam Oxazepam acetate Cinazepam Bentazepam Mexazolam
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		1 interacting genes: UBQLN1
Entrez ID		2559
HPRD ID		08841
Ensembl ID		ENSG00000145863
Uniprot IDs		Q16445
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Store-operated Calcium Channel Activity Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Aggrephagy Positive Regulation Of ERAD Pathway Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Transporter Activity Regulation Of ERAD Pathway Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Aggresome Negative Regulation Of Calcium Ion Transmembrane Transport Negative Regulation Of Calcium Ion Transport Autophagosome Maturation Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Proteasome Complex Autophagosome Kinase Binding Regulation Of Transmembrane Transporter Activity Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Cation Transmembrane Transport Autophagosome Organization Autophagosome Assembly Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway ERAD Pathway Negative Regulation Of Monoatomic Ion Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transporter Activity Positive Regulation Of Protein Ubiquitination Negative Regulation Of Transmembrane Transport Positive Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Decreased Oxygen Levels Positive Regulation Of Post-translational Protein Modification Cellular Response To Hypoxia Regulation Of Calcium Ion Transmembrane Transport Protein-containing Complex Disassembly Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Cellular Response To Oxygen Levels Macroautophagy Vacuole Organization Regulation Of Protein Ubiquitination Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Macroautophagy Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Calcium Ion Transport Response To Endoplasmic Reticulum Stress Regulation Of Post-translational Protein Modification Regulation Of Monoatomic Cation Transmembrane Transport
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