IPMK

Description		inositol polyphosphate multikinase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Ciliary Basal Body
	Molecular Function	Nucleotide Binding Inositol-1,4,5-trisphosphate 6-kinase Activity Inositol-1,4,5,6-tetrakisphosphate 3-kinase Activity Inositol-1,3,4,5-tetrakisphosphate 6-kinase Activity Protein Binding ATP Binding Inositol-1,4,5-trisphosphate 3-kinase Activity Kinase Activity Transferase Activity Metal Ion Binding 1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity Inositol-1,3,4,6-tetrakisphosphate 5-kinase Activity Inositol Tetrakisphosphate Kinase Activity Flavonoid Binding Inositol Phosphate Kinase Activity
	Biological Process	Lipid Metabolic Process Inositol Trisphosphate Metabolic Process Inositol Phosphate Biosynthetic Process Inositol Phosphate Metabolic Process Phosphatidylinositol Metabolic Process Necroptotic Process
Pathways		Synthesis of IPs in the nucleus
Drugs
Diseases
GWAS		Cerebrospinal fluid clusterin levels ( 26545630) Coronary artery calcification ( 23870195) Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233 28067908) Metabolite levels ( 23823483) Monocyte count ( 32888494) Nonsyndromic cleft lip with or without cleft palate x sex interaction (2df test) ( 30277614) Obesity-related traits ( 23251661) Plasma anti-thyroglobulin levels ( 29678681)
Interacting Genes		2 interacting genes: HSF2BP TRAF6
Entrez ID		253430
HPRD ID		17153
Ensembl ID		ENSG00000151151
Uniprot IDs		Q8NFU5
PDB IDs		5W2G 5W2H 5W2I 6E7F 6M88 6M89 6M8A 6M8B 6M8C 6M8D 6M8E 8V6W 8V6X 8V6Y 8V6Z 8V70 8V71 8V72 8V73 8V74 8V75 8V76 8V77 8V78 8V79
Enriched GO Terms of Interacting Partners?		Bone Resorption DNA-templated Transcription Positive Regulation Of T Cell Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway Ubiquitin-ubiquitin Ligase Activity CD40 Signaling Pathway Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Receptor Localization To Synapse Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Nucleobase-containing Compound Biosynthetic Process Non-canonical NF-kappaB Signal Transduction Bone Remodeling Myeloid Dendritic Cell Differentiation Interleukin-1-mediated Signaling Pathway Positive Regulation Of Osteoclast Differentiation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II CD40 Receptor Complex Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell DNA Damage Response Regulation Of Protein Localization To Synapse Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of JUN Kinase Activity Ubiquitin Conjugating Enzyme Binding MyD88-independent Toll-like Receptor Signaling Pathway Endolysosomal Toll-like Receptor Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Tumor Necrosis Factor Receptor Binding Interleukin-17A-mediated Signaling Pathway Protein Branched Polyubiquitination Protein Kinase B Binding Interleukin-33-mediated Signaling Pathway Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Myeloid Dendritic Cell Activation Toll-like Receptor 3 Signaling Pathway Cellular Response To Lectin Regulation Of Lipopolysaccharide-mediated Signaling Pathway T-helper 1 Type Immune Response Fc-epsilon Receptor Signaling Pathway Interleukin-17-mediated Signaling Pathway Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Male Meiosis I Double-strand Break Repair Involved In Meiotic Recombination Female Meiotic Nuclear Division Female Meiosis I Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Dendritic Cell Differentiation Positive Regulation Of Interleukin-2 Production Positive Regulation Of MAP Kinase Activity Activation Of Protein Kinase Activity Antigen Processing And Presentation Of Exogenous Peptide Antigen
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