FUT2

Description		fucosyltransferase 2 (H blood group)
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Membrane Golgi Cisterna Membrane Extracellular Exosome
	Molecular Function	Protein Binding Galactoside 2-alpha-L-fucosyltransferase Activity Fucosyltransferase Activity Transferase Activity Glycosyltransferase Activity Alpha-(1,2)-fucosyltransferase Activity
	Biological Process	Regulation Of Endothelial Cell Proliferation Carbohydrate Metabolic Process Protein Glycosylation Lipid Metabolic Process Glycolipid Metabolic Process Glycosphingolipid Biosynthetic Process Oligosaccharide Biosynthetic Process Regulation Of Cell Adhesion Fucosylation L-fucose Catabolic Process
Pathways		ABO blood group biosynthesis Lewis blood group biosynthesis Glycosphingolipid biosynthesis
Drugs
Diseases
GWAS		Alcohol use disorder (consumption score) ( 33861876) Alcohol use disorder (total score) ( 30336701) Anti-polyomavirus 2 IgG seropositivity ( 33204752) Apolipoprotein B levels ( 32203549) Behcet's disease ( 24326010) Bipolar disorder ( 21926972) Birth weight ( 31043758) BK polyomavirus VP1 antibody levels ( 33204752) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Body size at age 10 ( 32376654) Childhood asthma with severe exacerbations ( 33328473) Childhood ear infection ( 27182965 28928442) Cholesterol, total ( 20686565) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Cooked vegetable consumption ( 32066663) Crohn's disease ( 23128233 28067908 21102463 20570966) diarrhoeal disease at age 1 with doctor diagnosis ( 27559109) Dietary macronutrient intake ( 23372041) Elevated serum carcinoembryonic antigen levels ( 24941225) Estimated glomerular filtration rate ( 31015462) Fish- and plant-related diet ( 32066663) Folate pathway vitamin levels ( 19744961 19303062) Fruit consumption ( 32066663) Gallstone disease ( 30504769) Hemoglobin levels ( 32327693) Homocysteine levels ( 23824729) Inflammatory bowel disease ( 28067908) Iron status biomarkers (ferritin levels) ( 33536631) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipoprotein (a) levels ( 33730874) Liver enzyme levels (alkaline phosphatase) ( 33972514 22001757) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Low density lipoprotein cholesterol levels ( 32154731) Lung adenocarcinoma ( 28604730) Meat-related diet ( 32066663) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic traits ( 21886157) Mitochondrial heteroplasmy measurement ( 33731350) Mumps ( 28928442) Non-oily fish consumption ( 32066663) Obesity-related traits ( 23251661) Oily fish consumption ( 32066663) Pediatric autoimmune diseases ( 26301688) Pork consumption ( 32066663) Primary sclerosing cholangitis ( 27992413) Problematic alcohol use ( 32451486) Processed meat consumption ( 32066663) Psoriasis ( 25574825 28537254) Resting metabolic rate ( 28476931) Retinal vascular caliber ( 21060863) Schizophrenia ( 33169155) Serum cancer antigen 19.9 levels ( 31666285) Serum carcinoembryonic antigen levels ( 31666285) Serum lipase activity ( 25028398) Serum metabolite levels ( 33031748) Tumor biomarkers ( 23300138) Type 1 diabetes ( 25751624) Urinary metabolites (H-NMR features) ( 24586186) Vitamin B levels in ischemic stroke ( 25147783) Vitamin B12 levels ( 28334792 22367966 18776911)
Interacting Genes		1 interacting genes: ZDHHC17
Entrez ID		2524
HPRD ID		01629
Ensembl ID		ENSG00000176920
Uniprot IDs		A8K2L2 Q10981
PDB IDs
Enriched GO Terms of Interacting Partners?		Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Perforant Pathway To Dendrate Granule Cell Synapse Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-stearoyltransferase Activity Lipoprotein Transport Regulation Of Neurotrophin TRK Receptor Signaling Pathway Protein Palmitoylation Palmitoyltransferase Activity Regulation Of Modification Of Synaptic Structure Golgi-associated Vesicle Membrane Protein-cysteine S-palmitoyltransferase Activity Protein Lipidation Presynaptic Membrane Acyltransferase Activity Axonogenesis Cytoplasmic Vesicle Membrane
Tagcloud ?