BHMT2

Description		betaine--homocysteine S-methyltransferase 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Extracellular Exosome
	Molecular Function	Methyltransferase Activity S-methyltransferase Activity Zinc Ion Binding Transferase Activity Metal Ion Binding Betaine-homocysteine S-methyltransferase Activity S-methylmethionine-homocysteine S-methyltransferase Activity
	Biological Process	Modified Amino Acid Metabolic Process Amino-acid Betaine Metabolic Process Methionine Biosynthetic Process Methylation S-methylmethionine Metabolic Process S-adenosylmethionine Metabolic Process L-methionine Salvage
Pathways		Sulfur amino acid metabolism
Drugs		Methionine
Diseases
GWAS		Betaine levels in individuals undergoing cardiac evaluation ( 26822151) Blood and toenail selenium levels ( 25343990) Blood trace element (Se levels) ( 23720494) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) Metabolite levels ( 23378610 23823483) Serum metabolite levels ( 33031748) Toenail selenium levels ( 25343990)
Interacting Genes		1 interacting genes: APP
Entrez ID		23743
HPRD ID		12069
Ensembl ID		ENSG00000132840
Uniprot IDs		Q9H2M3
PDB IDs
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle Insulin Receptor Binding Apolipoprotein Binding Response To Lead Ion Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel High-density Lipoprotein Particle Very-low-density Lipoprotein Particle Neuron Projection Maintenance RAGE Receptor Binding
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