SPO11

Description		SPO11 initiator of meiotic double strand breaks
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome Chromosome, Telomeric Region Nucleus Chromosome
	Molecular Function	DNA Binding Catalytic Activity DNA Topoisomerase Activity DNA Topoisomerase Type II (double Strand Cut, ATP-hydrolyzing) Activity Protein Binding ATP Binding Isomerase Activity Metal Ion Binding
	Biological Process	Meiotic DNA Double-strand Break Processing Ovarian Follicle Development DNA Metabolic Process Homologous Chromosome Pairing At Meiosis Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Male Meiosis I Spermatogenesis Spermatid Development Female Gamete Generation Protein Localization To Chromosome Meiotic DNA Double-strand Break Formation Meiotic Telomere Clustering Oogenesis Meiotic Cell Cycle Double-strand Break Repair Involved In Meiotic Recombination
Pathways		Meiotic recombination
Drugs
Diseases
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494)
Interacting Genes		1 interacting genes: TCF4
Entrez ID		23626
HPRD ID		09236
Ensembl ID		ENSG00000054796
Uniprot IDs		Q9Y5K1
PDB IDs
Enriched GO Terms of Interacting Partners?		TFIIB-class Transcription Factor Binding Beta-catenin-TCF7L2 Complex Beta-catenin-TCF Complex
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