CLEC5A

Description		C-type lectin domain containing 5A
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Cell Surface Membrane Specific Granule Membrane Tertiary Granule Membrane
	Molecular Function	Virus Receptor Activity Carbohydrate Binding
	Biological Process	Positive Regulation Of Cytokine Production Osteoblast Development Immune System Process Cellular Defense Response Signal Transduction Myeloid Cell Differentiation Negative Regulation Of Myeloid Cell Apoptotic Process Negative Regulation Of Apoptotic Process Innate Immune Response Symbiont Entry Into Host Cell
Pathways		DAP12 interactions Neutrophil degranulation
Drugs
Diseases
GWAS		Anorexia nervosa ( 23568457) Compulsion score in obsessive compulsive disorder ( 32063569)
Interacting Genes		1 interacting genes: TYROBP
Entrez ID		23601
HPRD ID		09229
Ensembl ID		ENSG00000258227
Uniprot IDs		A4D1U7 Q14DL9 Q9NY25
PDB IDs		2YHF
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Osteoclast Development Microglial Cell Activation Involved In Immune Response Positive Regulation Of Microglial Cell Mediated Cytotoxicity Positive Regulation Of Receptor Localization To Synapse Stimulatory Killer Cell Immunoglobulin-like Receptor Signaling Pathway Positive Regulation Of Macrophage Fusion Negative Regulation Of Transforming Growth Factor Beta1 Production T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Neutrophil Activation Involved In Immune Response Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Osteoclast Development Negative Regulation Of Transforming Growth Factor Beta Production Negative Regulation Of B Cell Proliferation Positive Regulation Of Osteoclast Differentiation Negative Regulation Of Interleukin-10 Production Macrophage Activation Involved In Immune Response Regulation Of Superoxide Anion Generation Microglial Cell Activation Cellular Response To Lectin Regulation Of Receptor Localization To Synapse Positive Regulation Of Superoxide Anion Generation Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of Natural Killer Cell Activation Regulation Of Superoxide Metabolic Process Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Amyloid-beta Clearance Apoptotic Cell Clearance Neutrophil Activation Positive Regulation Of Protein Localization To Cell Surface Negative Regulation Of B Cell Activation Leukocyte Activation Involved In Inflammatory Response Regulation Of Protein Localization To Cell Surface Regulation Of Long-term Synaptic Potentiation Regulation Of Natural Killer Cell Activation Semaphorin-plexin Signaling Pathway Natural Killer Cell Mediated Immunity Negative Regulation Of Type I Interferon Production Osteoclast Differentiation Cellular Response To Amyloid-beta Cellular Defense Response Response To Axon Injury Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of B Cell Proliferation Macrophage Activation Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-1 Beta Production Response To Amyloid-beta Positive Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of Leukocyte Mediated Cytotoxicity T Cell Activation Involved In Immune Response
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