DDAH1

Description		dimethylarginine dimethylaminohydrolase 1
Image
GO Annotations	Cellular Component	Cytosol Extracellular Exosome
	Molecular Function	Catalytic Activity Dimethylargininase Activity Amino Acid Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Citrulline Metabolic Process Regulation Of Systemic Arterial Blood Pressure Arginine Metabolic Process L-arginine Catabolic Process Nitric Oxide Mediated Signal Transduction Negative Regulation Of Cell Population Proliferation Negative Regulation Of Vascular Permeability Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Nitric Oxide Metabolic Process Negative Regulation Of Cellular Response To Hypoxia
Pathways		eNOS activation
Drugs		Citrulline Pantoprazole Esomeprazole Dexlansoprazole
Diseases
GWAS		Asymmetrical dimethylarginine levels ( 24159190 25245031) Height ( 31562340) Multiple sclerosis ( 21833088 24076602) Obsessive-compulsive disorder or autism spectrum disorder ( 28641744) Pulse pressure ( 30224653) Serum dimethylarginine levels (asymmetric/symetric ratio) ( 24159190) Serum immune biomarker levels ( 32066700) Symmetrical dimethylarginine levels ( 24159190) Urinary metabolite levels in chronic kidney disease ( 31959995) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		1 interacting genes: CALM1
Entrez ID		23576
HPRD ID		09203
Ensembl ID		ENSG00000153904
Uniprot IDs		B2R644 B4DGT0 B4DYP1 B4E3V1 O94760
PDB IDs		2JAI 2JAJ 3I2E 3I4A 3P8E 3P8P 6DGE 6SZP 6SZQ 7ULU 7ULV 7ULX 7USZ 7UT0
Enriched GO Terms of Interacting Partners?		Mitochondrion-endoplasmic Reticulum Membrane Tethering Positive Regulation Of Sequestering Of Calcium Ion Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Autophagosome Membrane Docking Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Voltage-gated Calcium Channel Activity Titin Binding Detection Of Calcium Ion Calcium Channel Inhibitor Activity Regulation Of Cell Communication By Electrical Coupling Protein Phosphatase Activator Activity Calyx Of Held Negative Regulation Of Transporter Activity Cellular Response To Interferon-beta Catalytic Complex Presynaptic Cytosol Calcium Channel Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cardiac Muscle Cell Action Potential Calcineurin-mediated Signaling Myelin Sheath Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Response To Interferon-beta Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Negative Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Presynaptic Endocytosis Spindle Microtubule Substantia Nigra Development Positive Regulation Of Receptor Signaling Pathway Via STAT Calcium Channel Regulator Activity Sperm Midpiece Negative Regulation Of Calcium Ion Transport G2/M Transition Of Mitotic Cell Cycle Long-term Synaptic Potentiation Cell Cycle G2/M Phase Transition Sarcomere Regulation Of Action Potential Neural Nucleus Development Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Transmembrane Transporter Activity Regulation Of Receptor Signaling Pathway Via JAK-STAT
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