NUP188

Description		nucleoporin 188
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Pore Cytosol Membrane Nuclear Pore Inner Ring
	Molecular Function	Structural Constituent Of Nuclear Pore
	Biological Process	RNA Export From Nucleus Protein Import Into Nucleus Nucleocytoplasmic Transport Protein Transport MRNA Transport
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases
GWAS
Novel Interacting Genes		1 novel interacting genes: ATE1
Interacting Genes		1 interacting genes: NUP98
Entrez ID		23511
HPRD ID		18582
Ensembl ID		ENSG00000095319
Uniprot IDs		Q5SRE5
PDB IDs		5IJO 7R5J 7R5K
Enriched GO Terms of Interacting Partners?		Telomere Tethering At Nuclear Periphery Arginyl-tRNA--protein Transferase Activity Post-transcriptional Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Establishment Of Protein Localization To Organelle Protein Arginylation Nuclear Pore Cytoplasmic Filaments Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway Nuclear Pore Outer Ring Nuclear Pore Nuclear Basket Protein Localization To Organelle Nuclear Inclusion Body Telomere Localization Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Nuclear Pore Organization Nuclear Pore Complex Assembly Intracellular Protein Transport Protein Targeting To Vacuole Involved In Autophagy Nuclear Periphery Protein K27-linked Ubiquitination Pore Complex Assembly Nuclear Localization Sequence Binding Structural Constituent Of Nuclear Pore Peptide Binding Positive Regulation Of MRNA Splicing, Via Spliceosome Protein Transport Intracellular Transport Proteolysis Positive Regulation Of RNA Splicing Establishment Of Protein Localization Molecular Condensate Scaffold Activity Protein Targeting To Vacuole Establishment Of Protein Localization To Vacuole Cellular Localization Establishment Of Localization In Cell Promoter-specific Chromatin Binding Protein K63-linked Ubiquitination RNA Export From Nucleus Chromosome Localization Nuclear Pore Intracellular Protein Localization Nucleus Organization Protein Localization To Vacuole Regulation Of MRNA Splicing, Via Spliceosome Nuclear Export Import Into Nucleus MRNA Transport Serine-type Peptidase Activity Protein Import Into Nucleus Regulation Of MRNA Processing Positive Regulation Of MRNA Metabolic Process
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