PASK

Description		PAS domain containing serine/threonine kinase
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Lipid Binding Kinase Activity Transferase Activity Phosphatidylinositol Binding Protein Serine Kinase Activity
	Biological Process	Protein Phosphorylation Intracellular Signal Transduction Regulation Of Respiratory Gaseous Exchange Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Translation Protein Autophosphorylation Regulation Of Glucagon Secretion Energy Homeostasis
Pathways
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Height ( 23456168 31562340) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172)
Interacting Genes		3 interacting genes: IRS1 PIK3R1 PRKAA1
Entrez ID		23178
HPRD ID		06328
Ensembl ID		ENSG00000115687
Uniprot IDs		B7Z7R6 Q96RG2
PDB IDs		1LL8 3DLS
Enriched GO Terms of Interacting Partners?		Carbohydrate Homeostasis Phosphatidylinositol 3-kinase Binding Glucose Homeostasis Insulin-like Growth Factor Receptor Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Insulin Receptor Binding Cellular Response To Hormone Stimulus Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of D-glucose Import Phosphotyrosine Residue Binding Negative Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of D-glucose Transmembrane Transport Negative Regulation Of Insulin Receptor Signaling Pathway Regulation Of Establishment Of Protein Localization Regulation Of Lipid Catabolic Process Regulation Of D-glucose Import Response To Hormone Insulin Receptor Signaling Pathway Regulation Of D-glucose Transmembrane Transport Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cellular Response To Insulin Stimulus Intracellular Glucose Homeostasis Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Insulin Stimulus Intracellular Signaling Cassette Cellular Response To Oxygen-containing Compound Chemical Homeostasis Positive Regulation Of Cell Population Proliferation Regulation Of Protein Localization Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Glucosylceramide Biosynthetic Process Positive Regulation Of Lipid Metabolic Process Response To UV Regulation Of Protein Localization To Nucleus Positive Regulation Of Small Molecule Metabolic Process Response To Insulin Positive Regulation Of Intracellular Signal Transduction Glycerophospholipid Biosynthetic Process Cellular Response To Peptide Hormone Stimulus Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Homeostatic Process Phospholipid Biosynthetic Process Negative Regulation Of Protein Localization Kinase Regulator Activity Perinuclear Endoplasmic Reticulum Membrane Cold Acclimation Positive Regulation Of Mitochondrial Transcription Protein Stabilization Glycerophospholipid Metabolic Process
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