WDR43

Description		WD repeat domain 43
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GO Annotations	Cellular Component	Chromatin Fibrillar Center Nucleus Nucleoplasm Nucleolus Small-subunit Processome
	Molecular Function	RNA Polymerase II Complex Binding Transcription Elongation Factor Activity RNA Binding Protein Binding
	Biological Process	Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Regulation Of DNA-templated Transcription RRNA Processing Regulation Of Transcription Elongation By RNA Polymerase II Ribosome Biogenesis Ribosomal Small Subunit Biogenesis Positive Regulation Of Transcription By RNA Polymerase I Regulation Of Stem Cell Population Maintenance Positive Regulation Of RRNA Processing
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Breast cancer ( 27117709) Breast cancer (estrogen-receptor negative) ( 27117709 29058716) Iron status biomarkers (ferritin levels) ( 33536631)
Interacting Genes		1 interacting genes: RNF10
Entrez ID		23160
HPRD ID		19518
Ensembl ID		ENSG00000163811
Uniprot IDs		Q15061
PDB IDs		7MQ8 7MQ9 7MQA
Enriched GO Terms of Interacting Partners?		Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Postsynapse To Nucleus Signaling Pathway Negative Regulation Of Schwann Cell Proliferation Extrinsic Component Of Postsynaptic Density Membrane Positive Regulation Of Myelination Negative Regulation Of Glial Cell Proliferation Regulation Of Glial Cell Proliferation Negative Regulation Of Gliogenesis Regulation Of Myelination Postsynaptic Signal Transduction Protein Monoubiquitination Protein Autoubiquitination Regulation Of Gliogenesis Cytosolic Ribosome Regulation Of Nervous System Process Negative Regulation Of Nervous System Development Negative Regulation Of Neurogenesis
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