LRCH1

Description		leucine rich repeats and calponin homology domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm
	Molecular Function	Protein Binding
	Biological Process	Negative Regulation Of GTPase Activity Cellular Response To Chemokine Negative Regulation Of T Cell Migration
Pathways
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Immature fraction of reticulocytes ( 32888494) Mean platelet volume ( 27863252 32888494) Mosquito bite size ( 28199695) Optic disc size ( 31809533) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494) PR interval ( 30679814 32439900 30046033) PR segment duration ( 24850809) Pulse pressure ( 30578418) QRS complex (12-leadsum) ( 27659466) Systolic blood pressure ( 30224653)
Novel Interacting Genes		1 novel interacting genes: RB1
Interacting Genes		2 interacting genes: TMEM14A TMEM14B
Entrez ID		23143
HPRD ID		14307
Ensembl ID		ENSG00000136141
Uniprot IDs		Q9Y2L9
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Myofibroblast Differentiation Regulation Of G1/S Transition Of Mitotic Cell Cycle Sister Chromatid Biorientation Maintenance Of Mitotic Sister Chromatid Cohesion Regulation Of Lipid Kinase Activity Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Hepatocyte Apoptotic Process Enucleate Erythrocyte Differentiation Negative Regulation Of Apoptotic Signaling Pathway Glial Cell Apoptotic Process Regulation Of Cell Cycle G1/S Phase Transition Rb-E2F Complex Regulation Of Centromere Complex Assembly Chromatin Lock Complex Positive Regulation Of Collagen Fibril Organization Mitochondrial Membrane Regulation Of Myofibroblast Differentiation Regulation Of Apoptotic Signaling Pathway Regulation Of Collagen Fibril Organization Cyclin/CDK Positive Transcription Elongation Factor Complex Importin-alpha Family Protein Binding Positive Regulation Of Transcription Regulatory Region DNA Binding Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of Macrophage Differentiation Positive Regulation Of DNA Binding Positive Regulation Of Mitotic Metaphase/anaphase Transition Hepatocyte Apoptotic Process Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Glial Cell Proliferation Negative Regulation Of Membrane Permeability Negative Regulation Of Mitochondrial Membrane Permeability Heme Biosynthetic Process Disordered Domain Specific Binding Positive Regulation Of Extracellular Matrix Organization Negative Regulation Of Epithelial Cell Apoptotic Process Regulation Of Macrophage Differentiation Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Tetrapyrrole Biosynthetic Process Porphyrin-containing Compound Biosynthetic Process Glial Cell Proliferation Neuron Maturation Cell Population Proliferation Regulation Of Cell Cycle Process SWI/SNF Complex Myoblast Differentiation Positive Regulation Of Chromosome Separation
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