TTLL5

Description		tubulin tyrosine ligase like 5
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Plasma Membrane Cilium Ciliary Basal Body Cell Projection
	Molecular Function	Nucleotide Binding ATP Binding Tubulin Binding Ligase Activity Metal Ion Binding Tubulin-glutamic Acid Ligase Activity Protein-glutamic Acid Ligase Activity, Initiating Protein-glutamic Acid Ligase Activity, Elongating
	Biological Process	Sperm Axoneme Assembly Retina Development In Camera-type Eye
Pathways		Carboxyterminal post-translational modifications of tubulin
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Height ( 21998595) Large artery stroke ( 24262325) Lead levels ( 26025379)
Interacting Genes		4 interacting genes: CDKN1A CREB3 FXR1 NRIP1
Entrez ID		23093
HPRD ID		08309
Ensembl ID		ENSG00000119685
Uniprot IDs		Q6EMB2
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Nucleobase-containing Compound Metabolic Process Ovarian Follicle Rupture Positive Regulation Of Deacetylase Activity Nucleolus PCNA-p21 Complex Negative Regulation Of Cardiac Muscle Tissue Regeneration Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Oncogene-induced Cell Senescence Stress-induced Premature Senescence Cellular Response To Cell-matrix Adhesion RNA Strand Annealing Activity Nuclear Pore Localization Intracellular Membraneless Organelle CCR1 Chemokine Receptor Binding Release From Viral Latency Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Growth Nuclear Body Cellular Response To UV-B Negative Regulation Of Cyclin-dependent Protein Kinase Activity Positive Regulation Of Catalytic Activity Negative Regulation Of Cell Cycle Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Replicative Senescence Costamere Positive Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Long-term Synaptic Potentiation Ribonucleoprotein Granule Nuclear Pore Organization Positive Regulation Of MiRNA-mediated Gene Silencing Nuclear Pore Complex Assembly Ovulation Nuclear Glucocorticoid Receptor Binding Induction Of Positive Chemotaxis CAMP Response Element Binding Protein Binding Mitotic G1 DNA Damage Checkpoint Signaling Nuclear Retinoic Acid Receptor Binding Mitotic G1/S Transition Checkpoint Signaling Nuclear Retinoid X Receptor Binding Translation Regulator Activity Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of RNA Metabolic Process Pore Complex Assembly Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Macromolecule Biosynthetic Process Response To UV-B Regulation Of Macromolecule Biosynthetic Process
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