KDM4C

Description		lysine demethylase 4C
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Pericentric Heterochromatin
	Molecular Function	Transcription Coactivator Activity Zinc Ion Binding Oxidoreductase Activity Enzyme Binding Histone Demethylase Activity Histone H3K9 Demethylase Activity Metal Ion Binding Nuclear Androgen Receptor Binding Dioxygenase Activity Histone H3K36 Demethylase Activity Histone H3K9me2/H3K9me3 Demethylase Activity
	Biological Process	Blastocyst Formation Chromatin Organization Chromatin Remodeling Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression Stem Cell Population Maintenance Androgen Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Androgen Receptor Signaling Pathway Regulation Of Stem Cell Differentiation
Pathways		HDMs demethylate histones Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Drugs
Diseases
GWAS		Adult body size ( 32376654) Alanine aminotransferase levels ( 33547301 33339817) Alanine transaminase levels ( 29403010) Artificially sweetened beverage consumption ( 31046077) Body mass index ( 25673413) Body size at age 10 ( 32376654) Caffeine consumption from tea ( 33287642) California verbal learning test score ( 31596458) HIV-1 susceptibility ( 25786224) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Menarche (age at onset) ( 25231870) Radiation response ( 20923822) Response to fenofibrate (adiponectin levels) ( 23149075) Schizophrenia ( 30285260) Serum metabolite levels ( 31636271 33031748) Serum metabolite levels (CMS) ( 31636271) Systemic lupus erythematosus ( 26606652) Systemic vasculitis ( 29374629)
Interacting Genes		4 interacting genes: DSCAM H3C1 H3C14 TP53
Entrez ID		23081
HPRD ID		12016
Ensembl ID		ENSG00000107077
Uniprot IDs		B0QZ60 Q9H3R0
PDB IDs		2XDP 2XML 4XDO 4XDP 5FJH 5FJK 5KR7
Enriched GO Terms of Interacting Partners?		Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Central Nervous System Development Cellular Component Assembly Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Chromatin Remodeling Negative Regulation Of Pentose-phosphate Shunt Chromatin Organization Negative Regulation Of Helicase Activity Oxidative Stress-induced Premature Senescence Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Negative Regulation Of G1 To G0 Transition Glucose Catabolic Process To Lactate Via Pyruvate Germ Cell Nucleus Protein Heterodimerization Activity Cellular Response To Actinomycin D Nucleosome Nucleosome Assembly Protein-DNA Complex Assembly Nucleosome Organization Structural Constituent Of Chromatin Positive Regulation Of Thymocyte Apoptotic Process Response To Actinomycin D T Cell Proliferation Involved In Immune Response Histone Deacetylase Regulator Activity Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Regulation Of G1 To G0 Transition Glial Cell Apoptotic Process Cellular Response To UV-C ATP-dependent DNA/DNA Annealing Activity Positive Regulation Of Axon Extension Involved In Axon Guidance B Cell Lineage Commitment Regulation Of Pentose-phosphate Shunt Epigenetic Regulation Of Gene Expression Mitochondrial DNA Repair Protein-containing Complex Assembly Bone Marrow Development Stress-induced Premature Senescence Gene Expression Regulation Of NADP Metabolic Process Negative Regulation Of MiRNA Processing Netrin-activated Signaling Pathway Protein-containing Complex Organization TFIID-class Transcription Factor Complex Binding Positive Regulation Of Programmed Necrotic Cell Death Cellular Response To Antibiotic Chromosome Organization Macromolecule Biosynthetic Process
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