NMNAT2

Description		nicotinamide nucleotide adenylyltransferase 2
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Late Endosome Golgi Apparatus Trans-Golgi Network Cytosol Membrane Extrinsic Component Of Membrane Transport Vesicle Axon Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Cell Projection Synapse
	Molecular Function	Nucleotide Binding Nicotinamide-nucleotide Adenylyltransferase Activity Catalytic Activity Nicotinate-nucleotide Adenylyltransferase Activity ATP Binding Transferase Activity Nucleotidyltransferase Activity Protein ADP-ribosyltransferase-substrate Adaptor Activity
	Biological Process	Cytoplasmic Translation NADP+ Biosynthetic Process Nicotinamide Metabolic Process Nucleotide Biosynthetic Process NAD+ Biosynthetic Process Pyridine Nucleotide Biosynthetic Process 'de Novo' NAD+ Biosynthetic Process From L-tryptophan NAD+ Biosynthetic Process Via The Salvage Pathway Axon Development Organophosphate Biosynthetic Process Negative Regulation Of Cytoplasmic Translation
Pathways		Nicotinate metabolism
Drugs
Diseases
GWAS		Clozapine-induced agranulocytosis ( 25187353) General cognitive ability ( 29844566) Moderate-to-late spontaneous preterm birth ( 31194736) Morning person ( 30696823) Obesity-related traits ( 23251661) Reaction time ( 29844566) Systemic lupus erythematosus ( 28714469) Systemic lupus erythematosus and Systemic sclerosis ( 23740937)
Interacting Genes		2 interacting genes: APP MYCBP2
Entrez ID		23057
HPRD ID		09786
Ensembl ID		ENSG00000157064
Uniprot IDs		Q9BZQ4
PDB IDs
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Regulation Of Cell Junction Assembly Cell Projection Morphogenesis Regulation Of Synapse Assembly Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Synapse Organization Regulation Of Response To Calcium Ion Regulation Of Developmental Growth Regulation Of Chemotaxis Amylin Binding Neuron Projection Morphogenesis Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Axonogenesis Axon Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Regulation Of Protein Catabolic Process Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Neuron Projection Development Axon Choice Point Recognition Branchiomotor Neuron Axon Guidance Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Regulation Of Synaptic Assembly At Neuromuscular Junction Regulation Of Growth
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