PLCH1

Description		phospholipase C eta 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Phospholipase C Activity Calcium Ion Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Metal Ion Binding Calcium-dependent Phospholipase C Activity
	Biological Process	Lipid Metabolic Process Signal Transduction Lipid Catabolic Process Intracellular Signal Transduction Phosphatidylinositol Metabolic Process Phosphatidylinositol-mediated Signaling Release Of Sequestered Calcium Ion Into Cytosol
Pathways		Synthesis of IP3 and IP4 in the cytosol
Drugs
Diseases
GWAS		Heel bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		1 interacting genes: USP7
Entrez ID		23007
HPRD ID		11438
Ensembl ID		ENSG00000114805
Uniprot IDs		A0A2U3TZV8 Q4KWH8
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Establishment Of Protein Localization To Telomere Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Retrograde Transport, Endosome To Golgi Monoubiquitinated Protein Deubiquitination DNA Alkylation Repair Transcription-coupled Nucleotide-excision Repair Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Regulation Of Telomere Capping Negative Regulation Of Gluconeogenesis K48-linked Deubiquitinase Activity Deubiquitinase Activity Nucleotide-excision Repair Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of TORC1 Signaling Regulation Of Gluconeogenesis Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process TORC1 Signaling Cysteine-type Endopeptidase Activity Negative Regulation Of Autophagy Negative Regulation Of Small Molecule Metabolic Process P53 Binding Cysteine-type Deubiquitinase Activity Autophagosome Organization Protein Deubiquitination Protein Modification By Small Protein Removal Autophagosome Assembly Regulation Of TORC1 Signaling Regulation Of Circadian Rhythm Negative Regulation Of TOR Signaling TOR Signaling Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Protein Catabolic Process Regulation Of Telomere Maintenance Regulation Of Glucose Metabolic Process PML Body Cysteine-type Peptidase Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Regulation Of TOR Signaling Vacuole Organization Negative Regulation Of Gene Expression, Epigenetic Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Autophagy Regulation Of DNA-binding Transcription Factor Activity Regulation Of Proteasomal Protein Catabolic Process Protein Stabilization Regulation Of Chromosome Organization
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