FGF3

Name	fibroblast growth factor 3
Structure	No pdb structure
Interactors	6 interactors: EBNA1BP2 FGFR1 FGFR2 FGFR3 FGFR4 RPS2
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm
	Molecular Function	Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Anatomical Structure Morphogenesis Neurogenesis Cell Differentiation Regulation Of Cell Migration Positive Regulation Of MAPK Cascade Regulation Of Developmental Process Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Division Negative Regulation Of Cardiac Muscle Tissue Development
Pathways	PI3K Cascade PIP3 activates AKT signaling FGFR1b ligand binding and activation FGFR2b ligand binding and activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Signaling by FGFR2 in disease FGFRL1 modulation of FGFR1 signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Diseases	Kaposi's sarcoma
GWAS	Attention deficit hyperactivity disorder ( 29325848 ) Breast cancer ( 20453838 ) Childhood ear infection ( 27182965 28928442 ) Craniofacial microsomia ( 26853712 ) Lean body mass ( 28552196 ) Monobrow ( 27182965 ) Protein quantitative trait loci ( 18464913 ) Urate levels in overweight individuals ( 25811787 ) White blood cell count (basophil) ( 29403010 )
Entrez ID	2248
HPRD ID	01289
Ensembl ID	ENSG00000186895
Uniprot IDs	A0A7U3JVY0 P11487
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Fibroblast Growth Factor Binding Fibroblast Growth Factor Receptor Activity Positive Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Protein Tyrosine Kinase Activity Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Regulation Of Catalytic Activity Receptor Complex Ventricular Zone Neuroblast Division Orbitofrontal Cortex Development Peptidyl-tyrosine Phosphorylation Forebrain Neuroblast Division Forebrain Ventricular Zone Progenitor Cell Division Biomineral Tissue Development Lung-associated Mesenchyme Development Endochondral Bone Growth Positive Regulation Of Hydrolase Activity Branching Involved In Salivary Gland Morphogenesis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Autophosphorylation Positive Regulation Of MAPK Cascade Protein Kinase Activity Bone Growth Heparin Binding Kinase Activity Positive Regulation Of ERK1 And ERK2 Cascade Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Mesenchymal Cell Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Gland Morphogenesis Cellular Response To Fibroblast Growth Factor Stimulus Midbrain Development Regulation Of Mesenchymal Cell Proliferation Bone Morphogenesis Positive Regulation Of Heart Growth Positive Regulation Of Protein Metabolic Process Response To Fibroblast Growth Factor Ureteric Bud Development Regulation Of Cardiac Muscle Cell Proliferation Regulation Of ERK1 And ERK2 Cascade Mesonephric Tubule Development Positive Regulation Of Cell Population Proliferation Mesonephric Epithelium Development Positive Regulation Of Organ Growth Regulation Of Developmental Growth