LEMD2

Description		LEM domain nuclear envelope protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nuclear Envelope Nuclear Inner Membrane Cytoplasm Endoplasmic Reticulum Spindle Cytoskeleton Membrane Nuclear Membrane Nuclear Periphery
	Molecular Function	Protein Binding
	Biological Process	Nuclear Envelope Organization Neurogenesis Skeletal Muscle Cell Differentiation Negative Regulation Of MAPK Cascade Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Heart Formation Protein Localization To Chromatin Nuclear Membrane Organization
Pathways		Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation Depolymerization of the Nuclear Lamina Sealing of the nuclear envelope (NE) by ESCRT-III
Drugs
Diseases
GWAS		Alzheimer's disease (age of onset) ( 22005931) Apolipoprotein A1 levels ( 32203549) Asthma and attention deficit hyperactivity disorder ( 31619474) Body mass index ( 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Crohn's disease ( 23850713) Metabolite levels ( 23823483) Multisite chronic pain ( 33830993) Obesity-related traits ( 23251661) Phosphorus levels ( 20558539) Regular attendance at a gym or sports club ( 29970889) Schizophrenia ( 30285260)
Interacting Genes		1 interacting genes: OGT
Entrez ID		221496
HPRD ID		13984
Ensembl ID		ENSG00000161904
Uniprot IDs		Q8NC56
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity Regulation Of Transcription By Glucose NSL Complex Acetylglucosaminyltransferase Activity Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Sin3-type Complex Histone Acetyltransferase Complex Negative Regulation Of Stem Cell Population Maintenance Regulation Of Protein Localization To Synapse Regulation Of Receptor Localization To Synapse Mitophagy Protein Localization To Lysosome Circadian Regulation Of Gene Expression Positive Regulation Of Stem Cell Population Maintenance Cellular Response To Glucose Stimulus Regulation Of Stem Cell Population Maintenance Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Carbohydrate Catabolic Process Regulation Of Gluconeogenesis Regulation Of ATP Metabolic Process Regulation Of Glycolytic Process Positive Regulation Of TORC1 Signaling Cellular Response To Carbohydrate Stimulus Regulation Of Necroptotic Process Negative Regulation Of Translational Initiation Negative Regulation Of Proteasomal Protein Catabolic Process Phosphatidylinositol-3,4,5-trisphosphate Binding Pyroptotic Inflammatory Response Cellular Response To Nutrient Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Autophagy Of Mitochondrion Positive Regulation Of Translational Initiation Regulation Of Rac Protein Signal Transduction Negative Regulation Of Protein Ubiquitination TORC1 Signaling Regulation Of Insulin Receptor Signaling Pathway Regulation Of Programmed Necrotic Cell Death Positive Regulation Of TOR Signaling Chromatin DNA Binding Intracellular Glucose Homeostasis TOR Signaling Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Purine Nucleotide Metabolic Process
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