RTKN2

Description		rhotekin 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane
	Molecular Function
	Biological Process	Signal Transduction Positive Regulation Of Cell Population Proliferation Hemopoiesis Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Diastolic blood pressure ( 19430483) Hip circumference adjusted for BMI ( 34021172) Hypothyroidism ( 27182965) Response to haloperidol in psychosis ( 24751813) Rheumatoid arthritis ( 23028356 24390342 30423114) Systemic lupus erythematosus ( 23273568) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		2 interacting genes: BRCA1 PACSIN1
Entrez ID		219790
HPRD ID		17863
Ensembl ID		ENSG00000182010
Uniprot IDs		Q8IZC4
PDB IDs
Enriched GO Terms of Interacting Partners?		Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Presynaptic Endocytic Zone Negative Regulation Of Centrosome Duplication Negative Regulation Of Centriole Replication BRCA1-A Complex Negative Regulation Of Cellular Component Organization XY Body BRCA1-B Complex Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Lateral Element Nuclear Ubiquitin Ligase Complex Cellular Response To Indole-3-methanol BRCA1-C Complex Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Gamma-tubulin Ring Complex Ubiquitin-modified Histone Reader Activity Response To Indole-3-methanol DNA Strand Resection Involved In Replication Fork Processing DNA Repair Complex Random Inactivation Of X Chromosome COPI-coated Vesicle Photoreceptor Ribbon Synapse Plasma Membrane Tubulation Positive Regulation Of Dendrite Development RNA Polymerase Binding Negative Regulation Of Fatty Acid Biosynthetic Process Sex-chromosome Dosage Compensation Dosage Compensation By Inactivation Of X Chromosome Regulation Of DNA Damage Checkpoint Regulation Of Centriole Replication Protein K6-linked Ubiquitination Positive Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Condensed Chromosome Mitotic G2 DNA Damage Checkpoint Signaling Postreplication Repair Negative Regulation Of Fatty Acid Metabolic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process Homologous Recombination Regulation Of Intracellular Estrogen Receptor Signaling Pathway Synaptic Vesicle Endocytosis Regulation Of Fatty Acid Biosynthetic Process Regulation Of Centrosome Duplication Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Vascular Endothelial Growth Factor Production Centrosome Cycle Condensed Nuclear Chromosome Positive Regulation Of Developmental Process
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