ALDH1B1

Description		aldehyde dehydrogenase 1 family member B1
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GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol
	Molecular Function	Aldehyde Dehydrogenase (NAD+) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor NAD Binding
	Biological Process	Carbohydrate Metabolic Process Ethanol Catabolic Process Aldehyde Metabolic Process
Pathways		Ethanol oxidation Mitochondrial protein degradation
Drugs		NADH
Diseases
GWAS		Alcohol consumption (drinkers vs non-drinkers) ( 31959922) Clostridioides difficle infection in antibiotics-users ( 33841421) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Longevity (100 years and older) ( 33948810) Metabolite levels ( 23823483) Pulse pressure ( 27841878) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure ( 27841878) Type 2 diabetes (age of onset) ( 28060188)
Novel Interacting Genes		1 novel interacting genes: FES
Interacting Genes		5 interacting genes: EXOSC10 FABP2 FILNC1 OGT XRN2
Entrez ID		219
HPRD ID		00005
Ensembl ID		ENSG00000137124
Uniprot IDs		A0A384MTJ7 P30837
PDB IDs		7MJC 7MJD 7RAD
Enriched GO Terms of Interacting Partners?		Cellular Response To Nutrient 3'-5'-RNA Exonuclease Activity Lipid Binding Exonuclease Activity Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Nuclear Polyadenylation-dependent SnoRNA Catabolic Process Nuclear Polyadenylation-dependent SnRNA Catabolic Process Nuclear Polyadenylation-dependent CUT Catabolic Process Nuclease Activity Nuclear-transcribed MRNA Catabolic Process Transcription Termination Site Sequence-specific DNA Binding MRNA Catabolic Process Apical Cortex Long-chain Fatty Acid Binding Response To Nutrient Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance RNA Catabolic Process SnRNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway RRNA Processing Nuclear Polyadenylation-dependent RRNA Catabolic Process Sno(s)RNA Catabolic Process Positive Regulation Of MRNA Cis Splicing, Via Spliceosome CUT Catabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity Termination Of RNA Polymerase II Transcription 5'-3' RNA Exonuclease Activity Poly(A)-dependent SnoRNA 3'-end Processing RRNA Metabolic Process Positive Regulation Of Monocyte Differentiation Cellular Response To Nutrient Levels RRNA 3'-end Processing Nucleolar Exosome (RNase Complex) Regulation Of Transcription By Glucose 5'-3' Exonuclease Activity Cellular Response To Vitamin D TRNA Decay Nuclear MRNA Surveillance NSL Complex Myoblast Proliferation Regulation Of Telomerase RNA Localization To Cajal Body Intestinal Lipid Absorption
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