ESD

Description		esterase D
Image
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Lumen Cytosol Cytoplasmic Vesicle Extracellular Exosome
	Molecular Function	Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Ester Bonds S-formylglutathione Hydrolase Activity Identical Protein Binding Methylumbelliferyl-acetate Deacetylase Activity Carboxylic Ester Hydrolase Activity
	Biological Process	Formaldehyde Catabolic Process
Pathways		Glutathione conjugation
Drugs		Glutathione
Diseases
GWAS		Blood protein levels ( 30072576) Metabolite levels ( 23823483)
Novel Interacting Genes		1 novel interacting genes: RB1
Interacting Genes		3 interacting genes: CRK GRB2 PLCG2
Entrez ID		2098
HPRD ID		00588
Ensembl ID		ENSG00000139684
Uniprot IDs		A0A140VJJ2 P10768
PDB IDs		3FCX
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Regulation Of Defense Response Response To Yeast Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Defense Response Ephrin Receptor Binding Protein Tyrosine Kinase Binding Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Protein-containing Complex Assembly B Cell Receptor Signaling Pathway Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Innate Immune Response Response To Fungus Regulation Of Immune System Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Scaffold Protein Binding Ras Protein Signal Transduction Cell Surface Receptor Signaling Pathway Negative Regulation Of Innate Immune Response Regulation Of Leukocyte Mediated Cytotoxicity Kinase Binding Regulation Of MAPK Cascade Guanyl-nucleotide Exchange Factor Adaptor Activity SH3 Domain Binding Positive Regulation Of Cell Cycle Phase Transition Regulation Of Reactive Oxygen Species Metabolic Process Helper T Cell Diapedesis Regulation Of Cellular Component Organization Protein Phosphorylated Amino Acid Binding Response To Cholecystokinin Antigen Receptor-mediated Signaling Pathway Grb2-EGFR Complex Intracellular Signaling Cassette Cellular Response To Peptide Hormone Stimulus Regulation Of Immune Response Cerebellar Neuron Development Regulation Of Cell Cycle G1/S Phase Transition Inositol Trisphosphate Biosynthetic Process Chromatin Lock Complex Negative Regulation Of Immune Response Protein-macromolecule Adaptor Activity Cellular Developmental Process Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Immune System Process Positive Regulation Of Protein-containing Complex Assembly Follicular B Cell Differentiation Sister Chromatid Biorientation Maintenance Of Mitotic Sister Chromatid Cohesion Regulation Of Lipid Kinase Activity Positive Regulation Of Collagen Fibril Organization
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