ENDOG

Description		endonuclease G
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Inner Membrane Perikaryon Perinuclear Region Of Cytoplasm
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity Magnesium Ion Binding Nucleic Acid Binding Nuclease Activity Endonuclease Activity DNA Endonuclease Activity RNA Endonuclease Activity DNA Nuclease Activity Protein Binding Hydrolase Activity Protein Homodimerization Activity Metal Ion Binding
	Biological Process	In Utero Embryonic Development DNA Catabolic Process Apoptotic DNA Fragmentation DNA Recombination DNA Damage Response Response To Mechanical Stimulus Positive Regulation Of Autophagy Negative Regulation Of TOR Signaling Mitochondrial DNA Catabolic Process Response To Estradiol Cellular Response To Oxidative Stress Response To Tumor Necrosis Factor Positive Regulation Of Apoptotic Process Response To Antibiotic Cellular Response To Calcium Ion Cellular Response To Glucose Stimulus Cellular Response To Hypoxia Positive Regulation Of Mitochondrial DNA Replication Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of Apoptotic DNA Fragmentation
Pathways
Drugs
Diseases
GWAS		Blood metabolite levels ( 26401656)
Interacting Genes		2 interacting genes: TNKS UBC
Entrez ID		2021
HPRD ID		02704
Ensembl ID		ENSG00000167136
Uniprot IDs		E5KNL5 Q14249
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Telomeric Negative Regulation Of Sister Chromatid Cohesion Positive Regulation Of Telomere Capping Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Localization To Chromosome, Telomeric Region NAD+-protein-aspartate ADP-ribosyltransferase Activity Telomerase Inhibitor Activity Regulation Of Telomere Capping Protein Auto-ADP-ribosylation NAD+-protein-glutamate ADP-ribosyltransferase Activity Protein Tag Activity Post-translational Protein Modification Pericentriolar Material Positive Regulation Of Telomere Maintenance Via Telomerase Peptidyl-threonine Phosphorylation Regulation Of Sister Chromatid Cohesion NAD+-protein Mono-ADP-ribosyltransferase Activity Protein Poly-ADP-ribosylation Positive Regulation Of Telomere Maintenance Via Telomere Lengthening NAD+ Poly-ADP-ribosyltransferase Activity Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Mitotic Spindle Pole Regulation Of Telomere Maintenance Via Telomerase Peptidyl-serine Phosphorylation Positive Regulation Of DNA Biosynthetic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Endocytic Vesicle Membrane Positive Regulation Of Telomere Maintenance Protein Modification Process Negative Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Nuclear Pore Mitotic Spindle Organization Spindle Assembly Nucleotidyltransferase Activity Protein Localization To Chromosome Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance
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