TET3

Description		tet methylcytosine dioxygenase 3
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GO Annotations	Cellular Component	Female Pronucleus Male Pronucleus Nucleus Chromosome Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Protein Binding Zinc Ion Binding Methyl-CpG Binding Oxidoreductase Activity 2-oxoglutarate-dependent Dioxygenase Activity Metal Ion Binding Dioxygenase Activity DNA 5-methylcytosine Dioxygenase Activity
	Biological Process	Chromatin Organization Protein O-linked Glycosylation Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Epigenetic Regulation Of Gene Expression Positive Regulation Of Gene Expression Via Chromosomal CpG Island Demethylation Epigenetic Programing Of Male Pronucleus Positive Regulation Of Transcription By RNA Polymerase II
Pathways		TET1,2,3 and TDG demethylate DNA Chromatin modifications during the maternal to zygotic transition (MZT)
Drugs
Diseases
GWAS		Bitter alcoholic beverage consumption ( 31046077) Dialysis-related mortality ( 21546767) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) General risk tolerance (MTAG) ( 30643258) Gestational age at birth (maternal effect) ( 28877031) Systemic lupus erythematosus ( 23273568 27399966 33272962)
Interacting Genes		1 interacting genes: APP
Entrez ID		200424
HPRD ID		19402
Ensembl ID		ENSG00000187605
Uniprot IDs		A0A5H1ZRP3 O43151
PDB IDs		4Z3C 8U2Y
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle Insulin Receptor Binding Apolipoprotein Binding Response To Lead Ion Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel High-density Lipoprotein Particle Very-low-density Lipoprotein Particle Neuron Projection Maintenance RAGE Receptor Binding
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