PAOX

Gene Name		polyamine oxidase (exo-N4-amino)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Peroxisomal Matrix
	Molecular Function	Receptor Binding Polyamine Oxidase Activity N(1),N(12)-diacetylspermine:oxygen Oxidoreductase (3-acetamidopropanal-forming) Activity Spermine:oxygen Oxidoreductase (spermidine-forming) Activity Spermidine:oxygen Oxidoreductase (3-aminopropanal-forming) Activity N1-acetylspermine:oxygen Oxidoreductase (3-acetamidopropanal-forming) Activity N1-acetylspermidine:oxygen Oxidoreductase (3-acetamidopropanal-forming) Activity
	Biological Process	Polyamine Metabolic Process Polyamine Biosynthetic Process Polyamine Catabolic Process Xenobiotic Metabolic Process Putrescine Biosynthetic Process Putrescine Catabolic Process Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process Spermidine Catabolic Process Spermine Catabolic Process Oxidation-reduction Process Positive Regulation Of Spermidine Biosynthetic Process
Pathways		Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Metabolism of amino acids and derivatives Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Biological oxidations PAOs oxidise polyamines to amines Amine Oxidase reactions Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective FMO3 causes Trimethylaminuria (TMAU) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Metabolism of polyamines Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Interconversion of polyamines Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Drugs
Diseases
GWAS
Protein-protein Interactions		1 interactors: PEX5
Entrez ID		196743
HPRD ID		10136
Ensembl ID		ENSG00000148832
Uniprot IDs		Q6QHF9
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Protein Homotetramerization Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Docking Negative Regulation Of Protein Homooligomerization Protein Import Into Peroxisome Membrane Protein To Membrane Docking Peroxisomal Membrane Transport Negative Regulation Of Protein Oligomerization Protein Import Into Peroxisome Matrix Protein Targeting To Peroxisome Establishment Of Protein Localization To Peroxisome Very Long-chain Fatty Acid Metabolic Process Cerebral Cortex Neuron Differentiation Regulation Of Protein Oligomerization Endoplasmic Reticulum Organization Fatty Acid Beta-oxidation Peroxisome Organization Positive Regulation Of Multicellular Organism Growth Intracellular Protein Transmembrane Transport Mitochondrial Membrane Organization Protein Transmembrane Transport Fatty Acid Oxidation Lipid Oxidation Fatty Acid Catabolic Process Cerebral Cortex Cell Migration Membrane Docking Regulation Of Multicellular Organism Growth Telencephalon Cell Migration Forebrain Cell Migration Protein Tetramerization Neuromuscular Process Negative Regulation Of Protein Complex Assembly Cellular Lipid Catabolic Process Positive Regulation Of Developmental Growth Cerebral Cortex Development Protein Import Protein Targeting To Membrane Neuron Migration Lipid Modification Carboxylic Acid Catabolic Process Pallium Development Central Nervous System Neuron Differentiation Positive Regulation Of Growth Establishment Of Protein Localization To Membrane Lipid Catabolic Process Telencephalon Development Regulation Of Developmental Growth Fatty Acid Metabolic Process Regulation Of Protein Complex Assembly Establishment Of Protein Localization To Organelle
Tagcloud ?		acetylpolyamine antizyme az biosynthesis catabolic chemoresistance conversely define degradation dnp73 drugs fosb genotoxic jun junb mechanistic mediator namely np73 overcome overexpressing oxidase polyamine precludes sirna suppressing tap73 upregulates widen