PAOX

Description		polyamine oxidase
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Peroxisome Peroxisomal Matrix Cytosol
	Molecular Function	Oxidoreductase Activity Polyamine Oxidase Activity N(1)-acetylpolyamine Oxidase (3-acetamidopropanal-forming) Activity
	Biological Process	Polyamine Catabolic Process Spermine Metabolic Process Putrescine Biosynthetic Process Putrescine Catabolic Process Spermidine Catabolic Process Spermine Catabolic Process Positive Regulation Of Spermidine Biosynthetic Process
Pathways		PAOs oxidise polyamines to amines Interconversion of polyamines Peroxisomal protein import Peroxisomal protein import
Drugs
Diseases
GWAS		Serum metabolite levels ( 33031748) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995)
Interacting Genes		1 interacting genes: PEX5
Entrez ID		196743
HPRD ID		10136
Ensembl ID		ENSG00000148832
Uniprot IDs		Q6QHF9
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Import Into Peroxisome Matrix, Translocation Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Peroxisome Targeting Sequence Binding Protein Import Into Peroxisome Matrix, Docking Protein Import Into Peroxisome Membrane Protein Import Into Peroxisome Matrix, Substrate Release Protein Targeting To Peroxisome Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Carrier Chaperone Protein Unfolding Protein Import Into Peroxisome Matrix Pexophagy Peroxisomal Membrane Transport Establishment Of Protein Localization To Peroxisome Cerebral Cortex Neuron Differentiation Receptor Recycling Peroxisome Organization Intracellular Protein Transmembrane Transport Cerebral Cortex Cell Migration Positive Regulation Of Multicellular Organism Growth Very Long-chain Fatty Acid Metabolic Process Forebrain Neuron Differentiation Telencephalon Cell Migration Forebrain Cell Migration Receptor Metabolic Process Peroxisomal Matrix Fatty Acid Beta-oxidation Protein Monoubiquitination Endoplasmic Reticulum Organization Peroxisomal Membrane Regulation Of Multicellular Organism Growth Protein Transmembrane Transport Fatty Acid Oxidation Fatty Acid Catabolic Process Lipid Oxidation Protein Tetramerization Cellular Response To Reactive Oxygen Species Neuromuscular Process Mitochondrial Membrane Organization Peroxisome Lipid Modification Central Nervous System Neuron Differentiation Protein-containing Complex Disassembly Negative Regulation Of Protein-containing Complex Assembly Neuron Migration Macroautophagy Positive Regulation Of Developmental Growth Response To Reactive Oxygen Species Establishment Of Protein Localization To Membrane
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