DUSP8

Name	dual specificity phosphatase 8
Structure
Interactors	1 interactors: CDC25A
GO Annotations	Cellular Component	Nucleus Cytoplasm
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/threonine Phosphatase Activity Hydrolase Activity Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity MAP Kinase Tyrosine Phosphatase Activity
	Biological Process	Signal Transduction Dephosphorylation Negative Regulation Of MAPK Cascade
Pathways	RAF-independent MAPK1/3 activation Negative regulation of MAPK pathway Signaling by MAPK mutants
GWAS	Brain morphology (MOSTest) ( 32665545 ) Diverticular disease ( 30177863 )
Entrez ID	1850
HPRD ID	03617
Ensembl ID	ENSG00000184545
Uniprot IDs	Q13202
PDB IDs	4JMK
GO Terms Enriched among Interactors ?	Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle Membrane Disassembly Mitotic Nuclear Membrane Disassembly Regulation Of G2/MI Transition Of Meiotic Cell Cycle Nuclear Membrane Disassembly Nuclear Envelope Organization Positive Regulation Of Meiotic Cell Cycle Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of DNA Replication Nuclear Membrane Organization G2/M Transition Of Mitotic Cell Cycle Cell Cycle G2/M Phase Transition Regulation Of Meiotic Cell Cycle Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Reproductive Process Protein-folding Chaperone Binding Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Protein Tyrosine Phosphatase Activity Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Protein Serine/threonine Kinase Activity Regulation Of DNA Replication Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Phosphoprotein Phosphatase Activity Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Reproductive Process Regulation Of Protein Kinase Activity Positive Regulation Of Cell Cycle Process Regulation Of Kinase Activity Positive Regulation Of DNA Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Regulation Of Protein Phosphorylation Protein Kinase Binding Response To Radiation Regulation Of Phosphorylation Cell Division Regulation Of Cell Cycle Phase Transition