PRICKLE2

Description		prickle planar cell polarity protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Postsynaptic Density Membrane Axon Dendrite Nuclear Membrane Axon Initial Segment
	Molecular Function	Zinc Ion Binding Metal Ion Binding
	Biological Process	Blastocyst Formation Wnt Signaling Pathway, Planar Cell Polarity Pathway Protein Localization To Axon
Pathways
Drugs
Diseases
GWAS		Coronary artery calcification ( 23870195) Diisocyanate-induced asthma ( 25918132) Folate pathway vitamin levels ( 19303062) prednisolone sensitivity in B-cell precursor acute lymphoblastic leukaemia ( 33002292) Seborrheic dermatitis ( 29203360) Systemic juvenile idiopathic arthritis ( 27927641) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		3 interacting genes: APP FBXO7 SMURF2
Entrez ID		166336
HPRD ID		16342
Ensembl ID		ENSG00000163637
Uniprot IDs		Q7Z3G6
PDB IDs
Enriched GO Terms of Interacting Partners?		Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Ubiquitin Ligase Complex Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Acetylcholine Receptor Activator Activity Membrane Raft PTB Domain Binding Regulation Of Canonical Wnt Signaling Pathway Regulation Of Neuron Apoptotic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Locomotion Regulation Of Intrinsic Apoptotic Signaling Pathway Endosome To Plasma Membrane Transport Vesicle Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Cell Communication Low-density Lipoprotein Particle Mediated Signaling Lewy Body Core Ubiquitin-protein Transferase Activity Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Wnt Signaling Pathway Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Positive Regulation Of Trophoblast Cell Migration Protein Heterodimerization Activity Axon Choice Point Recognition
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