CYP27B1

Description		cytochrome P450 family 27 subfamily B member 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Membrane Mitochondrial Membrane
	Molecular Function	Monooxygenase Activity Calcidiol 1-monooxygenase Activity Iron Ion Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Heme Binding Metal Ion Binding Secalciferol 1-monooxygenase Activity
	Biological Process	Alcohol Metabolic Process Lipid Metabolic Process Vitamin Metabolic Process Calcium Ion Transport Negative Regulation Of Cell Population Proliferation Lipid Biosynthetic Process Bone Mineralization Negative Regulation Of Cell Growth Regulation Of Bone Mineralization Response To Lipopolysaccharide Response To Vitamin D Response To Type II Interferon Calcitriol Biosynthetic Process From Calciol Vitamin D Metabolic Process Vitamin D Biosynthetic Process Vitamin D Catabolic Process Response To Estrogen Small Molecule Biosynthetic Process Positive Regulation Of Keratinocyte Differentiation Decidualization Calcium Ion Homeostasis G1 To G0 Transition Positive Regulation Of Vitamin D Receptor Signaling Pathway Cellular Response To Vitamin D
Pathways		Vitamin D (calciferol) metabolism Vitamins Defective CYP27B1 causes VDDR1A
Drugs		Alfacalcidol
Diseases		Type I diabetes mellitus
GWAS		Brain morphology (MOSTest) ( 32665545) Multiple sclerosis ( 19525955 21833088)
Novel Interacting Genes		8 novel interacting genes: ATF2 HOXC10 ITGB7 MARS1 MYL6 SMC3 TMEM50B TUT4
Interacting Genes
Entrez ID		1594
HPRD ID		02031
Ensembl ID		ENSG00000111012
Uniprot IDs		O15528
PDB IDs
Enriched GO Terms of Interacting Partners?		Abducens Nucleus Development Cellular Response To Anisomycin Growth Plate Cartilage Chondrocyte Differentiation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Positive Regulation Of Cardiac Muscle Myoblast Proliferation Facial Nucleus Development Histone H2B Acetyltransferase Activity Hypoglossal Nucleus Development H4 Histone Acetyltransferase Complex Positive Regulation Of Transforming Growth Factor Beta2 Production Growth Plate Cartilage Chondrocyte Proliferation Cis-regulatory Region Sequence-specific DNA Binding Cell-matrix Adhesion Involved In Ameboidal Cell Migration Integrin Alpha4-beta7 Complex Methionyl-tRNA Aminoacylation Methionine-tRNA Ligase Activity Establishment Of Meiotic Sister Chromatid Cohesion Stem Cell Population Maintenance Maintenance Of Cell Number RNA Uridylyltransferase Activity Polyuridylation-dependent MRNA Catabolic Process Response To Anisomycin NK T Cell Differentiation Detection Of Cell Density Immune Response In Gut-associated Lymphoid Tissue Transposable Element Silencing By MRNA Destabilization Meiotic Cohesin Complex Mediator Complex Binding Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Spinal Cord Motor Neuron Cell Fate Specification Unconventional Myosin Complex Cohesin Complex Establishment Of Mitotic Sister Chromatid Cohesion Mitotic Cohesin Complex Brainstem Development Regulation Of Transforming Growth Factor Beta2 Production Establishment Of Sister Chromatid Cohesion
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