LINGO2

Description		leucine rich repeat and Ig domain containing 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Synaptic Membrane Glutamatergic Synapse
	Molecular Function	Protein Binding Signaling Receptor Activity
	Biological Process	Positive Regulation Of Synapse Assembly
Pathways
Drugs
Diseases
GWAS		Adult body size ( 32376654) Alcohol dependence ( 24166409) Alzheimer's disease in hypertension-negative individuals ( 31055733) Apolipoprotein A1 levels ( 32203549) Bipolar disorder or body mass index ( 31754094) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 25673413 28892062 26961502 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Coffee consumption ( 31046077) Diffusing capacity of carbon monoxide ( 30694715) Early chronic obstructive pulmonary disease in never smokers ( 33235445) Endometrial cancer ( 24096698) General factor of neuroticism ( 30867560) Gut microbiota (bacterial taxa) ( 27694959) HDL cholesterol levels ( 32203549) High density lipoprotein cholesterol levels ( 29083408) Immunoglobulin A ( 20694011) Influenza A (H1N1) infection ( 26379185) Intracranial aneurysm ( 30823506) Migraine ( 27182965) Mild influenza (H1N1) infection ( 26379185) Motion sickness ( 25628336) Neurociticism ( 29500382) Number of sexual partners ( 30643258) Obesity ( 23563607) Obesity-related traits ( 23251661) Pharmacokinetics of olanzapine in severe mental disorder (concentration dose ratio) ( 25944848) Platelet reactivity in response to clopidogrel treatment ( 32472697) Schizophrenia ( 26198764) Spatial processing ( 31596458) Total intracranial volume ( 31530798) Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Type 2 diabetes ( 24390345 30297969) Waist circumference ( 25673412)
Interacting Genes		2 interacting genes: APP USP7
Entrez ID		158038
HPRD ID		08715
Ensembl ID		ENSG00000174482
Uniprot IDs		Q7L985
PDB IDs
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Epigenetic Regulation Of Gene Expression Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Amylin Binding Regulation Of Proteolysis Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Small Molecule Metabolic Process Regulation Of Protein Catabolic Process Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Regulation Of Establishment Of Protein Localization To Telomere Axon Choice Point Recognition Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Retrograde Transport, Endosome To Golgi Regulation Of Establishment Of Protein Localization Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Positive Regulation Of Catabolic Process Cellular Response To Manganese Ion Regulation Of Vesicle-mediated Transport Monoubiquitinated Protein Deubiquitination Antifungal Humoral Response Nuclear Envelope Lumen
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