CYP1B1

Description		cytochrome P450 family 1 subfamily B member 1
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GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Monooxygenase Activity Iron Ion Binding Protein Binding Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Lyase Activity Heme Binding Metal Ion Binding Testosterone 6-beta-hydroxylase Activity Estrogen 16-alpha-hydroxylase Activity Estrogen 2-hydroxylase Activity Hydroperoxy Icosatetraenoate Dehydratase Activity
	Biological Process	Angiogenesis Trabecular Meshwork Development Lipid Metabolic Process Fatty Acid Metabolic Process Steroid Catabolic Process Xenobiotic Metabolic Process Nitric Oxide Biosynthetic Process Cell Adhesion Steroid Metabolic Process Estrogen Metabolic Process Negative Regulation Of Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Toxin Metabolic Process Response To Toxic Substance Positive Regulation Of Vascular Endothelial Growth Factor Production Sterol Metabolic Process Arachidonate Metabolic Process Epoxygenase P450 Pathway Collagen Fibril Organization Negative Regulation Of Cell Migration Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Cell Adhesion Mediated By Integrin Xenobiotic Catabolic Process Hormone Metabolic Process Benzene-containing Compound Metabolic Process Retinol Metabolic Process Retinal Metabolic Process Positive Regulation Of Apoptotic Process Blood Vessel Endothelial Cell Migration Endothelial Cell Migration Positive Regulation Of Angiogenesis Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Membrane Lipid Catabolic Process Blood Vessel Morphogenesis Retina Vasculature Development In Camera-type Eye Retinal Blood Vessel Morphogenesis Cellular Response To Hydrogen Peroxide Endothelial Cell-cell Adhesion Omega-hydroxylase P450 Pathway Olefinic Compound Metabolic Process Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Endogenous sterols Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Defective CYP1B1 causes Glaucoma
Drugs		Genistein 2-Methoxyestradiol Naringenin Quercetin beta-Naphthoflavone Flavone Cannabidiol Nabiximols
Diseases		Primary open angle glaucoma
GWAS		Asthma (time to childhood onset) x early life tobacco smoke interaction ( 31379025) Basal cell carcinoma ( 31174203 33549134) Central corneal thickness ( 32528159) Cutaneous malignant melanoma ( 26237428 32341527) Frontal fibrosing alopecia ( 30850646) Keratinocyte cancer (MTAG) ( 31174203) Melanoma ( 28212542) Metabolite levels ( 23823483) Nevus count ( 30429480) Nevus count or cutaneous melanoma ( 30429480 32341527) Parkinson's disease ( 26227905)
Interacting Genes		1 interacting genes: HSPB2
Entrez ID		1545
HPRD ID		03464
Ensembl ID		ENSG00000138061
Uniprot IDs		Q16678 Q53TK1
PDB IDs		3PM0 6IQ5
Enriched GO Terms of Interacting Partners?		Somatic Muscle Development Protein Refolding Structural Constituent Of Eye Lens Response To Unfolded Protein Response To Heat Enzyme Activator Activity Unfolded Protein Binding Muscle Structure Development Response To Temperature Stimulus Protein Folding
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