COMMD7

Description		COMM domain containing 7
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GO Annotations	Cellular Component	Cytoplasmic Vesicle
	Molecular Function	Protein Binding NF-kappaB Binding
	Biological Process	Negative Regulation Of NF-kappaB Transcription Factor Activity Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of DNA-templated Transcription
Pathways		Neddylation
Drugs
Diseases
GWAS		Arterial stiffness index ( 31235810) Birth weight ( 31043758) Brain morphology (MOSTest) ( 32665545) Height ( 31562340) Metabolite levels ( 23823483) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Type 2 diabetes ( 25760438) White blood cell count (basophil) ( 29403010)
Interacting Genes		2 interacting genes: CHRM3 COMMD1
Entrez ID		149951
HPRD ID		13085
Ensembl ID		ENSG00000149600
Uniprot IDs		Q86VX2
PDB IDs		8ESD 8F2R 8F2U 8P0W
Enriched GO Terms of Interacting Partners?		Acetylcholine Binding Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Localization Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Saliva Secretion Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Activity Regulation Of Protein Transport Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Transport Sodium Channel Inhibitor Activity Positive Regulation Of Endocytic Recycling Negative Regulation Of Hypoxia-inducible Factor-1alpha Signaling Pathway Positive Regulation Of Cholesterol Import Regulation Of Cholesterol Import Positive Regulation Of Endosome To Plasma Membrane Protein Transport Regulation Of Plasma Lipoprotein Particle Levels Negative Regulation Of Sodium Ion Transmembrane Transport Plasma Membrane To Endosome Transport Negative Regulation Of Protein Localization To Cell Surface Negative Regulation Of Cellular Response To Hypoxia Negative Regulation Of Sodium Ion Transport Low-density Lipoprotein Particle Clearance Positive Regulation Of Transport G Protein-coupled Acetylcholine Receptor Signaling Pathway Synaptic Transmission, Cholinergic Regulation Of Protein Localization Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Regulation Of Cellular Response To Hypoxia Regulation Of Endocytic Recycling Cul2-RING Ubiquitin Ligase Complex Copper Ion Homeostasis Phosphatidic Acid Binding Positive Regulation Of Protein Localization To Cell Surface Phosphatidylinositol-3,4-bisphosphate Binding Plasma Lipoprotein Particle Clearance Phosphatidylinositol-3,5-bisphosphate Binding Positive Regulation Of Smooth Muscle Contraction Protein Localization To Cell Surface Positive Regulation Of Cholesterol Transport Regulation Of Sodium Ion Transmembrane Transport Phosphatidylinositol-3,4,5-trisphosphate Binding Regulation Of Protein Localization To Cell Surface Negative Regulation Of NF-kappaB Transcription Factor Activity Ligand-gated Ion Channel Signaling Pathway Acetylcholine Receptor Signaling Pathway Postsynaptic Signal Transduction Copper Ion Binding Positive Regulation Of Muscle Contraction G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
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