UNC45B

Description		unc-45 myosin chaperone B
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Z Disc A Band Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Hsp90 Protein Binding
	Biological Process	Lens Development In Camera-type Eye Protein Folding Muscle Organ Development Cell Differentiation
Pathways
Drugs
Diseases
GWAS		Systemic sclerosis ( 30247649)
Interacting Genes		2 interacting genes: CFTR STUB1
Entrez ID		146862
HPRD ID		10840
Ensembl ID		ENSG00000141161
Uniprot IDs		Q8IWX7
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein-folding Chaperone Binding Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Chaperone-mediated Protein Complex Assembly Response To Endoplasmic Reticulum Stress Positive Regulation Of Anion Channel Activity Positive Regulation Of Monoatomic Anion Transport Negative Regulation Of Vascular Associated Smooth Muscle Contraction Positive Regulation Of Enamel Mineralization Ubiquitin Conjugating Enzyme Complex Enzyme Binding Transepithelial Water Transport Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Chaperone-mediated Autophagy Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Regulation Of Hormone Levels TPR Domain Binding Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Regulation Of Vascular Associated Smooth Muscle Contraction Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Nuclear Inclusion Body Regulation Of Glucocorticoid Metabolic Process Negative Regulation Of Vasoconstriction Response To Misfolded Protein Cellular Response To Misfolded Protein Negative Regulation Of Smooth Muscle Contraction Golgi-associated Vesicle Membrane Cellular Response To Forskolin Response To Forskolin Positive Regulation Of ERAD Pathway Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Ubiquitin-ubiquitin Ligase Activity Negative Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of Smooth Muscle Cell Apoptotic Process Misfolded Protein Binding Chloride Transmembrane Transporter Activity Sperm Capacitation Negative Regulation Of Muscle Contraction ERBB2 Signaling Pathway Bicarbonate Transport Positive Regulation Of Mitophagy
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