NRG4

Description		neuregulin 4
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane
	Molecular Function	Protein Binding Growth Factor Activity Receptor Ligand Activity
	Biological Process	ERBB4-ERBB4 Signaling Pathway
Pathways		Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling Nuclear signaling by ERBB4 PIP3 activates AKT signaling GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Downregulation of ERBB2 signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants
Drugs
Diseases
GWAS		Blood urea nitrogen levels ( 31152163) Diastolic blood pressure ( 28270201) Estimated glomerular filtration rate ( 31015462 31152163 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Metabolite levels ( 23823483) Red blood cell count ( 32888494 27863252) Red blood cell traits ( 23222517) Serum uric acid levels ( 30993211) Systolic blood pressure ( 30578418 30224653) Urate levels ( 31578528 23263486) Urate levels in obese individuals ( 25811787)
Interacting Genes		6 interacting genes: CISD2 CREB3 ERBB4 ERGIC3 FATE1 LHFPL5
Entrez ID		145957
HPRD ID		14871
Ensembl ID		ENSG00000169752
Uniprot IDs		Q8WWG1
PDB IDs
Enriched GO Terms of Interacting Partners?		Establishment Of Planar Polarity Involved In Nephron Morphogenesis Endoplasmic Reticulum Membrane Positive Regulation Of Deacetylase Activity Cardiac Muscle Tissue Regeneration Neuregulin Receptor Activity Central Nervous System Morphogenesis Olfactory Bulb Interneuron Differentiation Epidermal Growth Factor Receptor Activity Protein Homodimerization Activity Endoplasmic Reticulum Retrograde Transporter Complex, Golgi To ER Transporter Complex Negative Regulation Of Mitochondrial Calcium Ion Concentration ERBB2-ERBB4 Signaling Pathway Release From Viral Latency ERBB4-ERBB4 Signaling Pathway CCR1 Chemokine Receptor Binding Mitochondrial Outer Membrane Negative Regulation Of Apoptotic Process
Tagcloud ?