SERPINA12

Description		serpin family A member 12
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity Molecular Function Inhibitor Activity
	Biological Process	Gluconeogenesis Lipid Biosynthetic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Gluconeogenesis Positive Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Lipid Biosynthetic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cholesterol Metabolic Process Regulation Of Triglyceride Metabolic Process
Pathways
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Interacting Genes		1 interacting genes: XIAP
Entrez ID		145264
HPRD ID		18038
Ensembl ID		ENSG00000165953
Uniprot IDs		Q8IW75
PDB IDs		4IF8 4Y3K 4Y40 5EI0
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Linear Polyubiquitination Regulation Of Apoptosis Involved In Tissue Homeostasis Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Protein Linear Polyubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Protein Polyubiquitination Copper Ion Homeostasis Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Execution Phase Of Apoptosis P38MAPK Cascade Protein Serine/threonine Kinase Binding Regulation Of Protein Polyubiquitination Cysteine-type Endopeptidase Inhibitor Activity Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Type I Interferon Production Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Type I Interferon Production Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Neuron Apoptotic Process Negative Regulation Of Cytokine-mediated Signaling Pathway Regulation Of BMP Signaling Pathway Protein K63-linked Ubiquitination Positive Regulation Of JNK Cascade Cytoplasmic Pattern Recognition Receptor Signaling Pathway Peptidase Inhibitor Activity Positive Regulation Of Protein Ubiquitination Negative Regulation Of Response To Cytokine Stimulus Positive Regulation Of Post-translational Protein Modification Regulation Of Type I Interferon Production Positive Regulation Of Wnt Signaling Pathway Regulation Of JNK Cascade Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Protein Ubiquitination
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