DOCK11

Description		dedicator of cytokinesis 11
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Small GTPase Binding
	Biological Process	B Cell Homeostasis Marginal Zone B Cell Differentiation Small GTPase-mediated Signal Transduction Regulation Of Rho Protein Signal Transduction Positive Regulation Of GTPase Activity Positive Regulation Of Filopodium Assembly
Pathways		CDC42 GTPase cycle RAC1 GTPase cycle Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Mean platelet volume ( 32888494)
Interacting Genes		1 interacting genes: CALM1
Entrez ID		139818
HPRD ID		06492
Ensembl ID		ENSG00000147251
Uniprot IDs		Q5JSL3
PDB IDs
Enriched GO Terms of Interacting Partners?		Mitochondrion-endoplasmic Reticulum Membrane Tethering Positive Regulation Of Sequestering Of Calcium Ion Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Autophagosome Membrane Docking Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Voltage-gated Calcium Channel Activity Titin Binding Detection Of Calcium Ion Calcium Channel Inhibitor Activity Regulation Of Cell Communication By Electrical Coupling Protein Phosphatase Activator Activity Calyx Of Held Negative Regulation Of Transporter Activity Cellular Response To Interferon-beta Catalytic Complex Presynaptic Cytosol Calcium Channel Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cardiac Muscle Cell Action Potential Calcineurin-mediated Signaling Myelin Sheath Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Response To Interferon-beta Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Negative Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Presynaptic Endocytosis Spindle Microtubule Substantia Nigra Development Positive Regulation Of Receptor Signaling Pathway Via STAT Calcium Channel Regulator Activity Sperm Midpiece Negative Regulation Of Calcium Ion Transport G2/M Transition Of Mitotic Cell Cycle Long-term Synaptic Potentiation Cell Cycle G2/M Phase Transition Sarcomere Regulation Of Action Potential Neural Nucleus Development Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Transmembrane Transporter Activity Regulation Of Receptor Signaling Pathway Via JAK-STAT
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