NDUFAF6

Description		NADH:ubiquinone oxidoreductase complex assembly factor 6
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Membrane
	Molecular Function	Protein Binding
	Biological Process	Mitochondrial Respiratory Chain Complex I Assembly
Pathways		Complex I biogenesis
Drugs
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Alcohol dependence symptom count ( 29460428) Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 24162737 30820047) Apolipoprotein A1 levels ( 32203549) Central corneal thickness ( 29760442 32528159) Fasting plasma glucose ( 31932636) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Intraocular pressure ( 29617998) Keratoconus ( 33649486) Liver enzyme levels (alanine transaminase) ( 33972514) Macular thickness ( 30535121) Myocardial infarction ( 33532862) Platelet distribution width ( 32888494) Pulse pressure ( 30578418 30224653) Red blood cell count ( 32888494) Serum uric acid levels ( 30993211 29403010) Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia ( 25710658)
Novel Interacting Genes		1 novel interacting genes: TMEM67
Interacting Genes		2 interacting genes: GUCD1 OTX1
Entrez ID		137682
HPRD ID		17553
Ensembl ID		ENSG00000156170
Uniprot IDs		A0A075B6P0 Q330K2
PDB IDs
Enriched GO Terms of Interacting Partners?		Diencephalon Morphogenesis Metencephalon Development Negative Regulation Of Centrosome Duplication MKS Complex Filamin Binding
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