ADH1C

Description		alcohol dehydrogenase 1C (class I), gamma polypeptide
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cilium Ciliary Basal Body
	Molecular Function	Alcohol Dehydrogenase (NAD+) Activity All-trans-retinol Dehydrogenase (NAD+) Activity Protein Binding Zinc Ion Binding Oxidoreductase Activity Metal Ion Binding Ethanol Dehydrogenase (NAD+) Activity
	Biological Process	Retinol Metabolic Process Retinoic Acid Metabolic Process
Pathways		RA biosynthesis pathway Ethanol oxidation
Drugs		NADH Fomepizole 2,3,4,5,6-Pentafluorobenzyl Alcohol N-1-methylheptylformamide 2-Ethoxyethanol Cholic Acid 4-Iodopyrazole Pyrazole Para-Bromobenzyl Alcohol 3-Butylthiolane 1-Oxide 5-beta-D-ribofuranosylnicotinamide adenine dinucleotide (R)-N-(1-Methyl-Hexyl)-Formamide Trifluoroethanol Cyclohexylformamide Cpad N-Formylpiperidine 2,3-Difluorobenzyl Alcohol 2,4-Difluorobenzyl Alcohol 2,4-Difluoro-1-(Hydroxymethyl)Benzene
Diseases
GWAS		Alcohol consumption ( 31358974 28937693) Alcohol consumption (drinks per week) ( 30643258) Alcohol consumption in current drinkers ( 28937693) Alcohol consumption over the past year ( 29058377) Alcohol dependence ( 28714907 33290381 24166409 23456092 22004471) Alcohol use disorder ( 30940813) Alcohol use disorder (consumption score) ( 30940813) Alcohol use disorder (total score) ( 30336701) Bitter alcoholic beverage consumption ( 31046077) Cerebral amyloid angiopathy x sex interaction in Alzheimer’s disease ( 34020725) Cerebrospinal fluid clusterin levels ( 26545630) Conduct disorder (maternal expressed emotions interaction) ( 18846501) Hematocrit ( 32888494) Hip circumference adjusted for BMI ( 34021172) Lung cancer ( 28604730) Oral cavity and pharyngeal cancer ( 21437268 27749845) Regular attendance at a pub or social club ( 29970889) Total cholesterol levels ( 30275531)
Novel Interacting Genes		1 novel interacting genes: PKD2
Interacting Genes
Entrez ID		126
HPRD ID		00066
Ensembl ID		ENSG00000248144
Uniprot IDs		P00326
PDB IDs		1HT0 1U3W
Enriched GO Terms of Interacting Partners?		Metanephric Cortical Collecting Duct Development Metanephric Cortex Development Metanephric Distal Tubule Development Metanephric Part Of Ureteric Bud Development Migrasome Polycystin Complex Metanephric Smooth Muscle Tissue Development Metanephric Ascending Thin Limb Development Renal Artery Morphogenesis Distal Tubule Development Cellular Response To Hydrostatic Pressure HLH Domain Binding Metanephric S-shaped Body Morphogenesis Detection Of Nodal Flow Calcium-induced Calcium Release Activity Basal Cortex Nephric Duct Development Mesonephric Duct Development S-shaped Body Morphogenesis Determination Of Liver Left/right Asymmetry Response To Hydrostatic Pressure Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Metanephric Mesenchyme Development Voltage-gated Monoatomic Cation Channel Activity Response To Water Voltage-gated Monoatomic Ion Channel Activity Metanephric Nephron Tubule Development Muscle Alpha-actinin Binding Metanephric Epithelium Development Protein Heterotetramerization Metanephric Tubule Development Actinin Binding Cytoplasmic Side Of Endoplasmic Reticulum Membrane Cation Channel Complex Voltage-gated Sodium Channel Activity Renal Tubule Morphogenesis Outward Rectifier Potassium Channel Activity Centrosome Duplication Smooth Muscle Tissue Development Nephron Tubule Development Embryonic Placenta Development Renal Tubule Development Protein Heterooligomerization Spinal Cord Development Lumenal Side Of Endoplasmic Reticulum Membrane Placenta Blood Vessel Development Voltage-gated Calcium Channel Activity Non-motile Cilium Cellular Response To Fluid Shear Stress Aorta Development
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