ACOT4

Description		acyl-CoA thioesterase 4
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GO Annotations	Cellular Component	Peroxisome Peroxisomal Matrix Cytosol
	Molecular Function	Succinyl-CoA Hydrolase Activity Hydrolase Activity Thiolester Hydrolase Activity Fatty Acyl-CoA Hydrolase Activity Carboxylic Ester Hydrolase Activity
	Biological Process	Very Long-chain Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Succinyl-CoA Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Acyl-CoA Metabolic Process Butyrate Metabolic Process Monocarboxylic Acid Metabolic Process Saturated Monocarboxylic Acid Metabolic Process Unsaturated Monocarboxylic Acid Metabolic Process Dicarboxylic Acid Metabolic Process Dicarboxylic Acid Catabolic Process Short-chain Fatty Acid Metabolic Process
Pathways		Beta-oxidation of very long chain fatty acids Peroxisomal protein import Peroxisomal protein import
Drugs
Diseases
GWAS		Hippocampal volume ( 25625606) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		1 interacting genes: PEX5
Entrez ID		122970
HPRD ID		17928
Ensembl ID		ENSG00000177465
Uniprot IDs		Q8N9L9
PDB IDs		3K2I
Enriched GO Terms of Interacting Partners?		Protein Import Into Peroxisome Matrix, Translocation Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Peroxisome Targeting Sequence Binding Protein Import Into Peroxisome Matrix, Docking Protein Import Into Peroxisome Membrane Protein Import Into Peroxisome Matrix, Substrate Release Protein Targeting To Peroxisome Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Carrier Chaperone Protein Unfolding Protein Import Into Peroxisome Matrix Pexophagy Peroxisomal Membrane Transport Establishment Of Protein Localization To Peroxisome Cerebral Cortex Neuron Differentiation Receptor Recycling Peroxisome Organization Intracellular Protein Transmembrane Transport Cerebral Cortex Cell Migration Positive Regulation Of Multicellular Organism Growth Very Long-chain Fatty Acid Metabolic Process Forebrain Neuron Differentiation Telencephalon Cell Migration Forebrain Cell Migration Receptor Metabolic Process Peroxisomal Matrix Fatty Acid Beta-oxidation Protein Monoubiquitination Endoplasmic Reticulum Organization Peroxisomal Membrane Regulation Of Multicellular Organism Growth Protein Transmembrane Transport Fatty Acid Oxidation Fatty Acid Catabolic Process Lipid Oxidation Protein Tetramerization Cellular Response To Reactive Oxygen Species Neuromuscular Process Mitochondrial Membrane Organization Peroxisome Lipid Modification Central Nervous System Neuron Differentiation Protein-containing Complex Disassembly Negative Regulation Of Protein-containing Complex Assembly Neuron Migration Macroautophagy Positive Regulation Of Developmental Growth Response To Reactive Oxygen Species Establishment Of Protein Localization To Membrane
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