PDZD8

Description		PDZ domain containing 8
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GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site
	Molecular Function	Protein Binding Zinc Ion Binding Lipid Binding Metal Ion Binding
	Biological Process	Lipid Transport Cytoskeleton Organization Regulation Of Cell Morphogenesis Mitochondrial Calcium Ion Homeostasis Mitochondrion-endoplasmic Reticulum Membrane Tethering
Pathways
Drugs
Diseases
GWAS		Body mass index ( 26426971) Chronotype ( 30696823) Early cardiac repolarization ( 22683750) Neurociticism ( 29500382) Photic sneeze reflex ( 27182965)
Interacting Genes		2 interacting genes: BARD1 ITSN1
Entrez ID		118987
HPRD ID		11423
Ensembl ID		ENSG00000165650
Uniprot IDs		Q8NEN9
PDB IDs		7F6J
Enriched GO Terms of Interacting Partners?		Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity Negative Regulation Of MRNA 3'-end Processing BRCA1-BARD1 Complex Clathrin-dependent Synaptic Vesicle Endocytosis BRCA1-A Complex BRCA1-B Complex Regulation Of MRNA 3'-end Processing Nuclear Ubiquitin Ligase Complex Negative Regulation Of Protein Export From Nucleus BRCA1-C Complex Ubiquitin-modified Histone Reader Activity Postsynaptic Endocytic Zone Postsynaptic Actin Cytoskeleton Positive Regulation Of Caveolin-mediated Endocytosis Regulation Of Caveolin-mediated Endocytosis Positive Regulation Of Growth Hormone Secretion Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Regulation Of Growth Hormone Secretion DNA Strand Resection Involved In Replication Fork Processing Regulation Of Modification Of Postsynaptic Structure Apical Dendrite Proline-rich Region Binding Intracellular Vesicle Regulation Of Modification Of Synaptic Structure Regulation Of DNA Damage Checkpoint Protein K6-linked Ubiquitination Maintenance Of Protein Location In Nucleus Clathrin-dependent Endocytosis Regulation Of Protein Export From Nucleus Negative Regulation Of Intracellular Protein Transport Homologous Recombination Positive Regulation Of Dendritic Spine Development Synaptic Vesicle Endocytosis Maintenance Of Protein Localization In Organelle Presynaptic Endocytosis Mitotic G2/M Transition Checkpoint Regulation Of Dendritic Spine Development Maintenance Of Protein Location In Cell Negative Regulation Of Intracellular Transport Maintenance Of Protein Location Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Transport Negative Regulation Of Cell Cycle G2/M Phase Transition Cellular Response To Ionizing Radiation Maintenance Of Location In Cell Clathrin-coated Pit Maintenance Of Location Cytoplasmic Ribonucleoprotein Granule
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