THEM4

Description		thioesterase superfamily member 4
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix Cytosol Plasma Membrane Membrane Ruffle Membrane Cell Projection
	Molecular Function	Protein Binding Hydrolase Activity Long-chain Fatty Acyl-CoA Hydrolase Activity
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Apoptotic Process Small Molecule Metabolic Process Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Pathways		PIP3 activates AKT signaling Activation of AKT2 Negative regulation of the PI3K/AKT network CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability Mitochondrial Fatty Acid Beta-Oxidation
Drugs
Diseases
GWAS		Asthma ( 31619474) Eye movement (horizontal position gain) ( 30120336) Eye movement in schizophrenia (horizontal position gain) ( 30120336) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite levels ( 24625756 33031748) Serum uric acid levels in response to allopurinol in gout ( 25676789) Urinary metabolite ratios in chronic kidney disease ( 29545352)
Interacting Genes		1 interacting genes: AKT1
Entrez ID		117145
HPRD ID		16215
Ensembl ID		ENSG00000159445
Uniprot IDs		A8K0C9 Q5T1C6
PDB IDs		4AE8 4GAH
Enriched GO Terms of Interacting Partners?		Response To Rapamycin Positive Regulation Of Protein Localization To Endoplasmic Reticulum Nitric-oxide Synthase Regulator Activity Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of SREBP Signaling Pathway Response To Insulin-like Growth Factor Stimulus Negative Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of TORC2 Signaling TRNA Stabilization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Potassium Channel Activator Activity Mammalian Oogenesis Stage RNA (guanine-N7)-methylation Negative Regulation Of Fatty Acid Transport Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Cellular Response To Peptide Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Maintenance Of Protein Location In Mitochondrion TRNA (guanine-N7)-methylation Activation-induced Cell Death Of T Cells Regulation Of Long-chain Fatty Acid Import Into Cell TORC2 Complex Binding Cellular Response To Rapamycin Peripheral Nervous System Myelin Maintenance Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Deoxyribonuclease Activity Negative Regulation Of Protein Localization To Lysosome Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of TRNA Methylation Positive Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Endodeoxyribonuclease Activity SREBP-SCAP Complex Retention In Endoplasmic Reticulum Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Maternal Placenta Development Regulation Of SREBP Signaling Pathway Maintenance Of Protein Localization In Endoplasmic Reticulum Anoikis PERK-mediated Unfolded Protein Response Negative Regulation Of PERK-mediated Unfolded Protein Response Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Protein K29-linked Ubiquitination Cellular Response To Ether Calcium Import Into The Mitochondrion Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Response To UV-A Regulation Of TORC2 Signaling Mammary Gland Epithelial Cell Differentiation
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