THEM4

Gene Name		thioesterase superfamily member 4
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Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Plasma Membrane Ruffle Membrane
	Molecular Function	Palmitoyl-CoA Hydrolase Activity
	Biological Process	Fatty Acid Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Protein Kinase B Signaling Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Activation of PKB Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade PI3K Cascade Signaling by PDGF DAP12 interactions GAB1 signalosome CD28 co-stimulation CD28 dependent PI3K/Akt signaling Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR Signaling by VEGF Downstream signal transduction Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling PI3K/AKT Signaling in Cancer Adaptive Immune System Costimulation by the CD28 family Activation of PKB PIP3 activates AKT signaling IRS-mediated signalling IGF1R signaling cascade VEGFA-VEGFR2 Pathway IRS-related events triggered by IGF1R PI3K events in ERBB2 signaling VEGFR2 mediated vascular permeability Downstream signaling of activated FGFR Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events NGF signalling via TRKA from the plasma membrane Negative regulation of the PI3K/AKT network Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PI3K Cascade
Drugs
Diseases
GWAS
Protein-protein Interactions		1 interactors: AKT1
Entrez ID		117145
HPRD ID		16215
Ensembl ID
Uniprot IDs		A8K0C9 Q5T1C6
PDB IDs		4AE8 4GAH
Enriched GO Terms of Interacting Partners?		Glycogen Cell Differentiation Involved In Embryonic Placenta Development Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Negative Regulation Of Fatty Acid Beta-oxidation Response To UV-A Activation-induced Cell Death Of T Cells Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Negative Regulation Of Fatty Acid Oxidation Positive Regulation Of Glycogen Biosynthetic Process Nitric Oxide Biosynthetic Process Negative Regulation Of Cell Size Negative Regulation Of Release Of Cytochrome C From Mitochondria Spongiotrophoblast Layer Development T Cell Apoptotic Process Regulation Of Fatty Acid Beta-oxidation Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Blood Vessel Endothelial Cell Migration Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Peripheral Nervous System Myelin Maintenance Response To Food Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Mammary Gland Epithelial Cell Differentiation Negative Regulation Of Fatty Acid Metabolic Process Negative Regulation Of Lipid Transport Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Monooxygenase Activity Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of Lipid Catabolic Process Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Labyrinthine Layer Blood Vessel Development Glycogen Biosynthetic Process Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Oxidative Stress-induced Cell Death Response To Epidermal Growth Factor Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Nitric Oxide Metabolic Process Negative Regulation Of JNK Cascade Protein Import Into Nucleus, Translocation Reactive Nitrogen Species Metabolic Process Positive Regulation Of Vasoconstriction Negative Regulation Of Mitochondrion Organization Myelin Maintenance Regulation Of Glycogen Biosynthetic Process Regulation Of Fatty Acid Oxidation Regulation Of Fatty Acid Transport Cell Differentiation Involved In Embryonic Placenta Development Negative Regulation Of Autophagy Negative Regulation Of Stress-activated MAPK Cascade
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