ARAP2

Description		ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
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GO Annotations	Cellular Component	Cytoplasm
	Molecular Function	GTPase Activator Activity Phosphatidylinositol-3,4,5-trisphosphate Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Signal Transduction Regulation Of Actin Cytoskeleton Organization
Pathways		RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC3 GTPase cycle
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (age of onset) ( 22959728) Diastolic blood pressure ( 30224653) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Gut microbiota (functional units) ( 27694959) Heschl's gyrus morphology ( 25130324) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Influenza A (H1N1) infection ( 26379185) Metabolic syndrome ( 31589552) Mild influenza (H1N1) infection ( 26379185) Motion sickness ( 25628336) Smoking initiation ( 33082346) Smoking status (ever vs never smokers) ( 30643258) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		4 interacting genes: CDC42 RAC1 RHOA SNCA
Entrez ID		116984
HPRD ID		09439
Ensembl ID		ENSG00000047365
Uniprot IDs		A7E2A5 Q8WZ64
PDB IDs		1X40 2COD
Enriched GO Terms of Interacting Partners?		Postsynapse Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Synapse Organization Positive Regulation Of Stress Fiber Assembly Membrane Invagination Non-canonical Wnt Signaling Pathway Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Supramolecular Fiber Organization G Protein Activity Regulation Of Protein-containing Complex Assembly Cell Junction Organization Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Organelle Organization Regulation Of Stress Fiber Assembly Regulation Of Cytoskeleton Organization Supramolecular Fiber Organization G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Negative Regulation Of Oxidative Phosphorylation Negative Regulation Of Cellular Respiration Thioesterase Binding Regulation Of Reactive Oxygen Species Metabolic Process Membrane Organization Establishment Or Maintenance Of Cell Polarity Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Cell-cell Junction Organization Cell Cortex Positive Regulation Of Cytoskeleton Organization Regulation Of Hydrogen Peroxide Metabolic Process Establishment Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Protein-containing Complex Assembly Regulation Of Cell-substrate Adhesion Regulation Of Oxidative Phosphorylation GTP-dependent Protein Binding Establishment Of Apical/basal Cell Polarity Polarized Epithelial Cell Differentiation Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Regulation Of Cell Junction Assembly Actin Filament Organization Regulation Of Actin Filament Organization Small GTPase-mediated Signal Transduction Regulation Of Microtubule-based Process Positive Regulation Of Lamellipodium Assembly Regulation Of Aerobic Respiration Wnt Signaling Pathway Regulation Of Locomotion Establishment Of Epithelial Cell Polarity Regulation Of Synaptic Vesicle Recycling Cerebral Cortex Cell Migration
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