OSBPL7

Description		oxysterol binding protein like 7
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Nuclear Membrane Perinuclear Endoplasmic Reticulum
	Molecular Function	Protein Binding Lipid Binding Cholesterol Binding Sterol Transfer Activity
	Biological Process	Bile Acid Biosynthetic Process Lipid Transport Regulation Of Autophagy Sterol Transport Cellular Response To Cholesterol Positive Regulation Of Proteasomal Protein Catabolic Process
Pathways		Synthesis of bile acids and bile salts
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Asthma ( 34103634 32296059 31619474) Asthma (childhood onset) ( 31036433) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 26426971) Cholesterol, total ( 20686565 24097068 25961943) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) LDL cholesterol ( 20686565 25961943 24097068) Pulse pressure ( 30224653) Type 2 diabetes ( 30054458) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408)
Novel Interacting Genes		1 novel interacting genes: IKZF3
Interacting Genes		2 interacting genes: GABARAPL2 SNCA
Entrez ID		114881
HPRD ID		09477
Ensembl ID		ENSG00000006025
Uniprot IDs		Q8WXP9 Q9BZF2
PDB IDs
Enriched GO Terms of Interacting Partners?		Beta-tubulin Binding Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity SNARE Binding Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Protein Catabolic Process Phospholipid Binding Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Negative Regulation Of Dopamine Metabolic Process Microtubule Binding Regulation Of Serotonin Uptake Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process Dopamine Uptake Involved In Synaptic Transmission Mitochondrial ATP Synthesis Coupled Electron Transport Cuprous Ion Binding Regulation Of Chaperone-mediated Autophagy Response To Iron(II) Ion Regulation Of Protein Catabolic Process Dopamine Biosynthetic Process Negative Regulation Of Catabolic Process Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Acyl-CoA Biosynthetic Process Negative Regulation Of Cellular Respiration Supramolecular Fiber Negative Regulation Of Oxidative Phosphorylation Cellular Response To Nitrogen Starvation Catecholamine Uptake Dopamine Uptake Positive Regulation Of Inositol Phosphate Biosynthetic Process SNARE Complex Assembly Cellular Response To Epinephrine Stimulus Positive Regulation Of Receptor Recycling Positive Regulation Of Neurotransmitter Secretion Regulation Of SNARE Complex Assembly Regulation Of Hydrogen Peroxide Metabolic Process Negative Regulation Of Microtubule Polymerization Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway ATP Synthesis Coupled Electron Transport Platelet Alpha Granule Membrane Synaptic Vesicle Priming Dopamine Transport Inclusion Body
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