CHIT1

Description		chitinase 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Specific Granule Lumen Tertiary Granule Lumen
	Molecular Function	Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Chitinase Activity Protein Binding Chitin Binding Endochitinase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds
	Biological Process	Polysaccharide Catabolic Process Carbohydrate Metabolic Process Chitin Catabolic Process Immune Response Response To Bacterium Polysaccharide Digestion
Pathways		Digestion of dietary carbohydrate Neutrophil degranulation
Drugs		2-acetylamino-2-deoxy-b-D-allopyranose 2-(Acetylamino)-2-Deoxy-6-O-Methyl-Alpha-D-Allopyranose Argifin Argadin Allosamizoline
Diseases
GWAS		Asthma ( 31959851) Clozapine-induced agranulocytosis ( 25187353)
Novel Interacting Genes		1 novel interacting genes: PTPRC
Interacting Genes
Entrez ID		1118
HPRD ID		02494
Ensembl ID		ENSG00000133063
Uniprot IDs		Q13231
PDB IDs		1GUV 1HKI 1HKJ 1HKK 1HKM 1LG1 1LG2 1LQ0 1WAW 1WB0 4WJX 4WK9 4WKA 4WKF 4WKH 5HBF 5NR8 5NRA 5NRF 6JJR 6JK6 6SO0 6ZE8
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Interleukin-4-mediated Signaling Pathway Positive Regulation Of Hematopoietic Stem Cell Migration Plasma Membrane Raft Distribution Negative Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Microglial Cell Activation Positive Regulation Of Isotype Switching To IgG Isotypes Protein Tyrosine Kinase Inhibitor Activity DN2 Thymocyte Differentiation Positive Regulation Of Gamma-delta T Cell Activation Membrane Raft Distribution Gamma-delta T Cell Differentiation Membrane Raft Localization Membrane Microdomain Bleb Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Bone Marrow Development Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of Gamma-delta T Cell Differentiation Positive Thymic T Cell Selection Alpha-beta T Cell Proliferation Negative Thymic T Cell Selection Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Positive T Cell Selection Negative Regulation Of Macrophage Activation Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Neuroinflammatory Response Response To Aldosterone Regulation Of Microglial Cell Activation Transmembrane Receptor Protein Tyrosine Phosphatase Activity Negative T Cell Selection Heparan Sulfate Proteoglycan Binding Ankyrin Binding Natural Killer Cell Differentiation Gamma-delta T Cell Activation Positive Regulation Of Humoral Immune Response Thymic T Cell Selection Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Alpha-beta T Cell Proliferation Negative Regulation Of Interleukin-2 Production Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Isotype Switching Membrane Raft Organization Spectrin Binding Negative Regulation Of Receptor Signaling Pathway Via STAT T Cell Selection Stem Cell Development Positive Regulation Of T Cell Mediated Cytotoxicity
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