NUDT4

Description		nudix hydrolase 4
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol
	Molecular Function	Endopolyphosphatase Activity RNA Binding Protein Binding Diphosphoinositol-polyphosphate Diphosphatase Activity Pyrophosphatase Activity Hydrolase Activity SnoRNA Binding Bis(5'-adenosyl)-hexaphosphatase Activity Bis(5'-adenosyl)-pentaphosphatase Activity Metal Ion Binding Inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate Diphosphatase Activity Inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase Activity Inositol-5-diphosphate-1,3,4,6-tetrakisphosphate Diphosphatase Activity 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity
	Biological Process	Calcium-mediated Signaling Intracellular Signal Transduction Diphosphoinositol Polyphosphate Metabolic Process Diadenosine Pentaphosphate Catabolic Process Diadenosine Hexaphosphate Catabolic Process Adenosine 5'-(hexahydrogen Pentaphosphate) Catabolic Process
Pathways		Synthesis of pyrophosphates in the cytosol
Drugs
Diseases
GWAS		Immature fraction of reticulocytes ( 32888494) Red cell distribution width ( 32888494)
Novel Interacting Genes		1 novel interacting genes: APAF1
Interacting Genes		1 interacting genes: KEAP1
Entrez ID		11163
HPRD ID		14850
Ensembl ID		ENSG00000173598
Uniprot IDs		A0A024RBG1 A0A0C4DGJ4 Q9NZJ9
PDB IDs		5LTU 7NNJ
Enriched GO Terms of Interacting Partners?		Response To G1 DNA Damage Checkpoint Signaling Regulation Of Apoptotic DNA Fragmentation Apoptosome Response To DNA Damage Checkpoint Signaling Cysteine-type Endopeptidase Activator Activity Negative Regulation Of Response To Oxidative Stress Cardiac Muscle Cell Apoptotic Process Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Striated Muscle Cell Apoptotic Process Protein-containing Complex Muscle Cell Apoptotic Process Inclusion Body Cellular Response To Interleukin-4 Disordered Domain Specific Binding Response To Interleukin-4 Regulation Of Response To Oxidative Stress Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress ADP Binding Transcription Regulator Inhibitor Activity
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