FOXN3

Description		forkhead box N3
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GO Annotations	Cellular Component	Chromatin Nucleus
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Mitotic G2 DNA Damage Checkpoint Signaling Negative Regulation Of DNA-templated Transcription Craniofacial Suture Morphogenesis
Pathways
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder symptom score ( 27663945) Body mass index ( 28552196) Cerebrospinal fluid clusterin levels ( 26545630) Copper levels ( 26025379) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Fasting blood glucose ( 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting glucose ( 34059833) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Glycated hemoglobin levels ( 34059833) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Idiopathic intracranial hypertension ( 29608535) Insular cortex volume ( 31530798) Intelligence (MTAG) ( 29326435) Liver fibrosis in non-alcoholic fatty liver disease ( 31311600) Metabolite levels ( 23823483) Multiple system atrophy (pathologically confirmed) ( 27629089) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Pulse pressure ( 30224653) Small cell lung carcinoma ( 28604730) Smoking initiation (ever regular vs never regular) ( 30679032) Weight loss (gastric bypass surgery) ( 23643386)
Interacting Genes		4 interacting genes: EXOSC8 MEN1 MFHAS1 SRPK2
Entrez ID		1112
HPRD ID		07533
Ensembl ID		ENSG00000053254
Uniprot IDs		O00409
PDB IDs		6NCE 6NCM
Enriched GO Terms of Interacting Partners?		T-helper 2 Cell Differentiation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cyclin-dependent Protein Kinase Activity MLL1/2 Complex Regulation Of JNK Cascade Y-form DNA Binding R-loop Processing Nuclear Speck Organization Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Toll-like Receptor 2 Signaling Pathway U5 SnRNA 3'-end Processing Exoribonuclease Complex U1 SnRNA 3'-end Processing Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRAMP-dependent TRNA Surveillance Pathway TRNA Surveillance TRNA Decay RRNA 3'-end Processing Nucleolar Exosome (RNase Complex) U4 SnRNA 3'-end Processing Nuclear MRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process Four-way Junction DNA Binding Intracellular Signal Transduction Osteoblast Development Nuclear Body Organization Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Cytoplasmic Exosome (RNase Complex) RRNA Catabolic Process Nuclear Exosome (RNase Complex) Exosome (RNase Complex) RNA Exonuclease Activity Immune System Process
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