KERA

Description		keratocan
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Extracellular Matrix Lysosomal Lumen
	Molecular Function
	Biological Process	Visual Perception Cornea Development In Camera-type Eye
Pathways		Keratan sulfate biosynthesis Keratan sulfate degradation Defective CHST6 causes MCDC1 Defective ST3GAL3 causes MCT12 and EIEE15 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Drugs
Diseases		Cornea plana congenita
GWAS		Pre-treatment viral load in HIV-1 infection ( 31219150) Pulmonary function (smoking interaction) ( 23284291) Systolic blood pressure (alcohol consumption interaction) ( 24376456)
Novel Interacting Genes		2 novel interacting genes: CHMP2A UNG
Interacting Genes
Entrez ID		11081
HPRD ID		04477
Ensembl ID		ENSG00000139330
Uniprot IDs		O60938
PDB IDs
Enriched GO Terms of Interacting Partners?		Somatic Hypermutation Of Immunoglobulin Genes Deoxyribose Phosphate Catabolic Process Isotype Switching Base-excision Repair, AP Site Formation Via Deaminated Base Removal Base-excision Repair, AP Site Formation Single Strand Break Repair Ribosomal Small Subunit Binding Uracil DNA N-glycosylase Activity Somatic Diversification Of Immunoglobulins Involved In Immune Response Somatic Diversification Of Immune Receptors Via Somatic Mutation Deoxyribonucleotide Catabolic Process Pyrimidine Deoxyribonucleotide Catabolic Process Hydrolase Activity, Hydrolyzing N-glycosyl Compounds Depyrimidination DNA Modification Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Pyrimidine-containing Compound Catabolic Process Plasma Membrane Repair Mitotic Cytokinetic Process ESCRT III Complex Multivesicular Body Membrane Negative Regulation Of Centriole Elongation Viral Budding From Plasma Membrane Amphisome Membrane Late Endosome To Lysosome Transport Lysosomal Membrane Organization Vesicle Fusion With Vacuole Kinetochore Microtubule Viral Budding Regulation Of Exosomal Secretion ESCRT III Complex Disassembly Nuclear Membrane Reassembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Mitotic Spindle Assembly Viral Release From Host Cell ESCRT Complex Disassembly Midbody Abscission Membrane Coat Multivesicular Body-lysosome Fusion Positive Regulation Of Exosomal Secretion Exit From Mitosis Phosphatidylcholine Binding Multivesicular Body Organization Multivesicular Body Assembly Regulation Of Spindle Assembly Somatic Recombination Of Immunoglobulin Gene Segments Base-excision Repair Late Endosome To Vacuole Transport Deoxyribonucleotide Metabolic Process
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