ADCY3

Description		adenylate cyclase 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Plasma Membrane Cilium Membrane Cell Projection Ciliary Membrane
	Molecular Function	Nucleotide Binding Adenylate Cyclase Activity Calmodulin Binding ATP Binding Lyase Activity Phosphorus-oxygen Lyase Activity Metal Ion Binding
	Biological Process	CAMP Biosynthetic Process Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Single Fertilization Acrosome Reaction Sensory Perception Of Smell Olfactory Learning Cyclic Nucleotide Biosynthetic Process Flagellated Sperm Motility Intracellular Signal Transduction Cellular Response To Forskolin
Pathways		Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway Olfactory Signaling Pathway G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state GPER1 signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs		Colforsin
Diseases
GWAS		Adult body size ( 32376654) Appendicular lean mass ( 33097823) BMI (adjusted for smoking behaviour) ( 28443625) BMI at 1 year old ( 31575865) BMI at 1.5 years old ( 31575865) BMI at 2 years old ( 31575865) BMI at 3 years old ( 31575865) BMI at 5 years old ( 31575865) BMI at 6 months old ( 31575865) BMI at 8 months old ( 31575865) BMI in non-smokers ( 28443625) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body fat mass ( 28552196) Body mass index ( 29381148 29273807 28892062 28552196 28448500 31453325 20935630 26961502 26426971 24861553 25953783 23583978 22344219 25673413) Body mass index (adult) ( 28430825) Body mass index (age <50) ( 26426971) Body mass index (age>50) ( 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in non-asthmatics ( 23517042) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Body mass index variance ( 31453325) Body mass index x sex x age interaction (4df test) ( 26426971) Body size at age 10 ( 32376654) Breast cancer ( 29059683) Childhood body mass index ( 33045005 26604143) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronotype ( 30696823) Coronary artery disease ( 29212778) Crohn's disease ( 28067908) Dentures ( 31235808) Diastolic blood pressure ( 27841878 30578418 28135244) Hand grip strength ( 29691431) Height ( 31562340 18391951 23563607 28552196) Height adjusted BMI ( 25044758) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Hip circumference ( 25673412 31453325) Hip circumference adjusted for BMI ( 34021172) Hip circumference variance ( 31453325) Inflammatory bowel disease ( 28067908 23128233) Multiple sclerosis ( 31604244) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Obese vs. thin ( 30677029) Obesity ( 23563607) Obesity (extreme) ( 30677029) Pubertal anthropometrics ( 23449627) Response to antidepressants (symptom improvement) ( 33589590) Reticulocyte count ( 27863252 32888494) Systolic blood pressure ( 30578418 27841878) Trunk fat mass ( 28552196) Type 1 diabetes ( 21980299) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		3 interacting genes: CAMK2G MTNR1B STOML3
Entrez ID		109
HPRD ID		02620
Ensembl ID		ENSG00000138031
Uniprot IDs		A0A0A0MSC1 B7ZLX9 O60266
PDB IDs
Enriched GO Terms of Interacting Partners?		Calcium-dependent Protein Serine/threonine Phosphatase Activity Calcium- And Calmodulin-dependent Protein Kinase Complex Neuron Projection Melatonin Receptor Activity Positive Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of CGMP-mediated Signaling Regulation Of Neuronal Action Potential Negative Regulation Of Transmission Of Nerve Impulse Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Regulation Of Skeletal Muscle Adaptation Negative Regulation Of Vasoconstriction Regulation Of CGMP-mediated Signaling Ion Channel Inhibitor Activity Regulation Of Hormone Levels Regulation Of System Process Negative Regulation Of Nervous System Process Regulation Of Transmission Of Nerve Impulse Negative Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Circadian Rhythm Calcium/calmodulin-dependent Protein Kinase Activity Regulation Of Circadian Sleep/wake Cycle Positive Regulation Of Behavior Sarcoplasmic Reticulum Membrane Negative Regulation Of Insulin Secretion Regulation Of Protein Localization Negative Regulation Of Peptide Secretion Insulin Secretion
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