CPSF4

Description		cleavage and polyadenylation specific factor 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	MRNA Processing
Pathways		Transport of Mature mRNA Derived from an Intronless Transcript Inhibition of Host mRNA Processing and RNA Silencing tRNA processing in the nucleus mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
Drugs
Diseases
GWAS		Diffuse cutaneous systemic sclerosis ( 29293537) Facial emotion recognition (sad faces) ( 28608620) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Serum metabolite levels ( 23093944) Tacrolimus trough concentration in kidney transplant patients ( 29160300)
Interacting Genes		10 interacting genes: CREBBP FIP1L1 MARK3 MEOX2 MID2 MIR19A MIR19B1 MIR92A2 MYOG SLC12A9
Entrez ID		10898
HPRD ID		04338
Ensembl ID		ENSG00000160917
Uniprot IDs		B7Z7B0 O95639
PDB IDs		2D9N 2RHK 6DNH 6FUW 6URG 6URO 7K95 7ZYH 8E3I 8E3Q 8R8R
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Striated Muscle Cell Differentiation Negative Regulation Of Cardiac Epithelial To Mesenchymal Transition Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Regulation Of Matrix Metallopeptidase Secretion Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Extracellular Matrix Assembly Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development RISC Complex Cellular Response To Bacterial Lipopeptide Negative Regulation Of Matrix Metallopeptidase Secretion Response To Bacterial Lipoprotein Negative Regulation Of Fibroblast Migration Muscle Cell Fate Commitment MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Extracellular Matrix Assembly Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Muscle Cell Differentiation Negative Regulation Of Extracellular Matrix Organization Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulatory NcRNA-mediated Gene Silencing Negative Regulation Of Inflammatory Response To Antigenic Stimulus Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Heart Growth Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Striated Muscle Cell Apoptotic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Protein Localization Regulation Of Fibroblast Migration Tau Protein Binding Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Muscle System Process Positive Regulation Of Organ Growth Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Interleukin-6 Production Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Muscle Cell Apoptotic Process MRNA Base-pairing Post-transcriptional Repressor Activity Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Reverse Cholesterol Transport Negative Regulation Of Apolipoprotein A-I-mediated Signaling Pathway Skeletal Muscle Tissue Development Regulation Of Heart Growth Regulation Of Extracellular Matrix Organization
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