ME3

Description		malic enzyme 3
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix
	Molecular Function	Malic Enzyme Activity Malate Dehydrogenase (decarboxylating) (NADP+) Activity Oxaloacetate Decarboxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Metal Ion Binding NADP Binding NAD Binding NADP+ Binding
	Biological Process	Pyruvate Metabolic Process Malate Metabolic Process Pyruvate Biosynthetic Process
Pathways		Pyruvate metabolism
Drugs		NADH Tartronate
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) ( 23648065) Adverse response to chemotherapy in breast cancer (alopecia) (anti-microtubule) ( 24025145) Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Calcific aortic valve stenosis ( 32141789) Glaucoma ( 30054594) Glaucoma (high intraocular pressure) ( 33627673) Glaucoma (primary open-angle) ( 33627673) Intraocular pressure ( 29785010 30054594 29617998 31959993) JT interval (sulfonylurea treatment interaction) ( 27958378) Lung function (FEV1) ( 28166213) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494) Refractive error ( 32231278) Sensorimotor dexterity ( 31596458) Urate levels in obese individuals ( 25811787)
Interacting Genes		2 interacting genes: RHOU RUNX1
Entrez ID		10873
HPRD ID		06862
Ensembl ID		ENSG00000151376
Uniprot IDs		B2R995 Q16798 Q6TCH8
PDB IDs		8E76 8E78 8E8O 8EYN 8EYO
Enriched GO Terms of Interacting Partners?		Cardiac Muscle Tissue Regeneration Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Core-binding Factor Complex Peripheral Nervous System Neuron Development Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD8-positive, Alpha-beta T Cell Activation Positive Regulation Of Granulocyte Differentiation Negative Regulation Of Granulocyte Differentiation Positive Regulation Of Focal Adhesion Disassembly Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Granulocyte Differentiation Regulation Of Anatomical Structure Morphogenesis Hematopoietic Stem Cell Proliferation Regulation Of CD8-positive, Alpha-beta T Cell Activation Regulation Of Plasminogen Activation Regulation Of Connective Tissue Replacement Positive Regulation Of Collagen Biosynthetic Process Rac Protein Signal Transduction Positive Regulation Of Extracellular Matrix Organization Positive Regulation Of Cellular Component Organization Chondrocyte Differentiation Negative Regulation Of Alpha-beta T Cell Differentiation Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Interleukin-2 Production Negative Regulation Of Lymphocyte Differentiation Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Transcription Coactivator Binding Regulation Of Protein Processing Regulation Of Collagen Metabolic Process Positive Regulation Of Alpha-beta T Cell Differentiation Tissue Regeneration Positive Regulation Of Myeloid Leukocyte Differentiation Transcription Corepressor Binding Regulation Of Collagen Biosynthetic Process Regulation Of Protein Maturation Negative Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of Interleukin-2 Production Negative Regulation Of CD4-positive, Alpha-beta T Cell Activation Negative Regulation Of T Cell Differentiation Negative Regulation Of Alpha-beta T Cell Activation Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Podosome Positive Regulation Of Protein Targeting To Mitochondrion Regulation Of Heart Growth Regulation Of Extracellular Matrix Organization Stem Cell Proliferation Positive Regulation Of Alpha-beta T Cell Activation Regulation Of Cell-substrate Junction Organization Regulation Of Tissue Remodeling
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