NPRL2

Description		NPR2 like, GATOR1 complex subunit
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GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Vacuolar Membrane Membrane GATOR1 Complex
	Molecular Function	GTPase Activator Activity Protein Binding
	Biological Process	Cytoplasmic Translation Positive Regulation Of Autophagy Cellular Response To Nutrient Levels Negative Regulation Of Kinase Activity Cellular Response To Amino Acid Starvation TORC1 Signaling Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Cellular Response To Methionine Protein Localization To Lysosome Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling
Pathways		Amino acids regulate mTORC1
Drugs
Diseases
GWAS		Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		3 interacting genes: ANXA7 CDKN1A RSPH1
Entrez ID		10641
HPRD ID		06147
Ensembl ID		ENSG00000114388
Uniprot IDs		Q8WTW4
PDB IDs		6CES 6CET 7T3A 7T3B 7T3C 8FW5
Enriched GO Terms of Interacting Partners?		PCNA-p21 Complex Negative Regulation Of Cardiac Muscle Tissue Regeneration Radial Spoke Head 1 Radial Spoke Head 3 Cellular Response To Cell-matrix Adhesion Oncogene-induced Cell Senescence Stress-induced Premature Senescence Outer Dense Fiber Radial Spoke Head Chromaffin Granule Membrane Epithelial Cell Differentiation Response To Phorbol 13-acetate 12-myristate Cellular Response To UV-B Negative Regulation Of Cyclin-dependent Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Replicative Senescence Meiotic Spindle Radial Spoke Mitotic G1 DNA Damage Checkpoint Signaling Mitotic G1/S Transition Checkpoint Signaling
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