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ST6GALNAC2
Gene Name
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Golgi Membrane
Integral Component Of Golgi Membrane
Molecular Function
Sialyltransferase Activity
Biological Process
Dolichol-linked Oligosaccharide Biosynthetic Process
Protein O-linked Glycosylation
O-glycan Processing
Protein N-linked Glycosylation Via Asparagine
Post-translational Protein Modification
Cellular Protein Metabolic Process
Sialylation
Pathways
Diseases of glycosylation
Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
Defective MGAT2 causes MGAT2-CDG (CDG-2a)
Defective ALG1 causes ALG1-CDG (CDG-1k)
Defective MOGS causes MOGS-CDG (CDG-2b)
O-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Defective ALG9 causes ALG9-CDG (CDG-1l)
Defective MAN1B1 causes MRT15
Defective ALG11 causes ALG11-CDG (CDG-1p)
Defective ALG2 causes ALG2-CDG (CDG-1i)
Defective ALG3 causes ALG3-CDG (CDG-1d)
Post-translational protein modification
Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
Termination of O-glycan biosynthesis
Synthesis of substrates in N-glycan biosythesis
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Defective ALG6 causes ALG6-CDG (CDG-1c)
Defective RFT1 causes RFT1-CDG (CDG-1n)
Asparagine N-linked glycosylation
Defective ALG8 causes ALG8-CDG (CDG-1h)
Sialic acid metabolism
Defective MPDU1 causes MPDU1-CDG (CDG-1f)
Defective ALG12 causes ALG12-CDG (CDG-1g)
O-linked glycosylation of mucins
Diseases associated with N-glycosylation of proteins
Drugs
Diseases
GWAS
Protein-protein Interactions
1 interactors:
SMAD3
Entrez ID
10610
HPRD ID
10231
Ensembl ID
ENSG00000070731
Uniprot IDs
Q9UJ37
PDB IDs
Enriched GO Terms of Interacting Partners
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Positive Regulation Of Transforming Growth Factor Beta3 Production
Evasion Or Tolerance Of Host Defenses By Virus
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Positive Regulation Of Extracellular Matrix Assembly
Regulation Of Extracellular Matrix Assembly
Primary MiRNA Processing
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
SMAD Protein Complex Assembly
Negative Regulation Of Osteoblast Proliferation
Transdifferentiation
Regulation Of Transforming Growth Factor Beta2 Production
Positive Regulation Of Catenin Import Into Nucleus
Positive Regulation Of Alkaline Phosphatase Activity
Paraxial Mesoderm Morphogenesis
Nodal Signaling Pathway
Positive Regulation Of Transforming Growth Factor Beta Production
Regulation Of Osteoblast Proliferation
Embryonic Foregut Morphogenesis
Positive Regulation Of Focal Adhesion Assembly
Positive Regulation Of Adherens Junction Organization
Production Of MiRNAs Involved In Gene Silencing By MiRNA
Foregut Morphogenesis
Modulation By Virus Of Host Morphology Or Physiology
Paraxial Mesoderm Development
Regulation Of Catenin Import Into Nucleus
Thyroid Gland Development
Osteoblast Development
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Chondrocyte Differentiation
Pericardium Development
Positive Regulation Of Phosphatase Activity
Positive Regulation Of Positive Chemotaxis
Positive Regulation Of Interleukin-1 Production
Signal Transduction Involved In Regulation Of Gene Expression
Activin Receptor Signaling Pathway
Lens Fiber Cell Differentiation
Positive Regulation Of Epithelial To Mesenchymal Transition
Gene Silencing By MiRNA
Positive Regulation Of Bone Mineralization
Cellular Response To DsRNA
Positive Regulation Of Transcription Factor Import Into Nucleus
Positive Regulation Of Biomineral Tissue Development
Positive Regulation Of Cartilage Development
Regulation Of Extracellular Matrix Organization
Posttranscriptional Gene Silencing
Positive Regulation Of Stress Fiber Assembly
Regulation Of Focal Adhesion Assembly
Positive Regulation Of Dephosphorylation
Negative Regulation Of Osteoblast Differentiation
Regulation Of Interleukin-1 Beta Production
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