WARS2

Description		tryptophanyl tRNA synthetase 2, mitochondrial
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GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix Plasma Membrane
	Molecular Function	Nucleotide Binding Aminoacyl-tRNA Ligase Activity Tryptophan-tRNA Ligase Activity ATP Binding Ligase Activity
	Biological Process	Vasculogenesis Translation TRNA Aminoacylation For Protein Translation Tryptophanyl-tRNA Aminoacylation Positive Regulation Of Angiogenesis Mitochondrial Tryptophanyl-tRNA Aminoacylation
Pathways		Mitochondrial tRNA aminoacylation
Drugs		Tryptophan
Diseases
GWAS		A body shape index ( 34021172) Body mass index ( 28892062) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hip index ( 34021172) Male-pattern baldness ( 28196072 29146897) Monobrow ( 27182965) Recurrent major depressive disorder ( 34099189) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172 25673412) Waist-hip index ( 34021172) Waist-hip ratio ( 20935629 25673412) Waist-to-hip ratio adjusted for BMI ( 28552196 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in inactive individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Novel Interacting Genes		1 novel interacting genes: PTPN22
Interacting Genes		1 interacting genes: APP
Entrez ID		10352
HPRD ID		05295
Ensembl ID		ENSG00000116874
Uniprot IDs		B7Z448 B7Z5X7 B7Z6G7 Q9UGM6
PDB IDs		5EKD
Enriched GO Terms of Interacting Partners?		Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of JNK Cascade Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Response To Calcium Ion Regulation Of Type II Interferon Production Regulation Of Tumor Necrosis Factor Production Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Interleukin-6 Production Positive Regulation Of Type II Interferon Production Positive Regulation Of ERK1 And ERK2 Cascade Phosphoanandamide Dephosphorylation Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of ERK1 And ERK2 Cascade Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission Positive Regulation Of MAPK Cascade NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Innate Immune Response Regulation Of Toll Signaling Pathway Positive Regulation Of Defense Response Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Axon Choice Point Recognition Positive Regulation Of Cytokine Production Heparan Sulfate Binding Signaling Receptor Activator Activity Positive Regulation Of Protein K63-linked Ubiquitination
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